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Magnesium Sulphate to Bupivicaine in Serratus Anterior Plane Block in Modified Radical Mastectomy

Effectiveness of Adding Magnesium Sulphate to Bupivicaine in Ultrasound Guided Serratus Anterior Plane Block in Patients Undergoing Modified Radical Mastectomy

Status
UNKNOWN
Phases
Phase 2Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04429893
Enrollment
80
Registered
2020-06-12
Start date
2022-01-01
Completion date
2022-09-30
Last updated
2022-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer Breast, Chronic Pain Syndrome

Keywords

serratus anterior plane block, magnesium sulphate

Brief summary

Modified radical mastectomy may be associated with severe post-operative pain, leading to chronic pain syndrome which usually requires optimal perioperative pain management.

Detailed description

Patients will be randomly into two equal groups (40 patients each) according to the adjuvant added to the local anesthetic (bupivacaine) in the serratus anterior plane block using a computer-generated random numbers concealed in sealed opaque envelopes. Group B: The patients will receive 20 ml of 0.5% bupivacaine plus 5 ml 0.9% normal saline with total volume 25 ml. Group BM: The patients will receive 20 ml of 0.5% bupivacaine plus 150 mg magnesium sulphate in 0.9% normal saline with a total volume of 25 ml.

Interventions

DRUGmagnesium sulphate

assess the pain intensity of magnesium sulphate as an adjuvant to bupivacaine in serratus anterior plane block for modified radical mastectomy

assess the pain intensity of magnesium sulphate as an adjuvant to bupivacaine in serratus anterior plane block for modified radical mastectomy

Sponsors

Alexandria University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
FEMALE
Age
20 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

* adult female patients * American Society Of Anesthesiologists (ASA) class I or II * scheduled for elective unilateral modified radical mastectomy

Exclusion criteria

* patient refusal * bilateral breast surgery * coagulation disorders * body mass index\> 35 * allergy to local anaesthetics or magnesium sulphate * severe respiratory or cardiac disorders * pre-existing neurological deficits * liver or renal insufficiency

Design outcomes

Primary

MeasureTime frameDescription
assessment of the pain intensity24 hoursPain assessment by visual analogue scale

Countries

Egypt

Contacts

Primary ContactRehab A. Abd Elaziz, Ass. Prof.
trcium2002@yahoo.com01001073703

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026