Portal Vein Pulsatility Flow in Pregnancy

Portal Vein Pulsatility Flow in Pregnancy - a Pilot Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04429178

Enrollment

Registered

2020-06-12

Start date

2020-08-13

Completion date

2022-03-01

Last updated

2022-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy

Keywords

portal vein pulsatility, physiologic volume overload

Brief summary

This study is to investigate if portal vein pulsatility fraction can be measured in pregnancy and if it increases during the course of pregnancy as would be expected by the physiologic increase in blood volume that happens during pregnancy. Portal vein pulsatility fraction is measured in non-pregnant controls and in women in the 1st, 2nd and 3rd trimester of pregnancy.

Interventions

OTHERultrasound

portal vein pulsatility fraction (percent) measured with ultrasound

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Ability to give informed consent * American Society of Anesthesiologists (ASA) Class I and II * Singleton pregnancy during 1st, 2nd or 3rd trimester or healthy non-pregnant females of childbearing age as controls

Exclusion criteria

* Inability to give informed consent * Multiple gestation * Significant co-morbidities (e.g. cardiac abnormalities, cardiac dysfunction, arrhythmias, severe asthma, renal insufficiency) * High risk pregnancies (e.g. pre-eclampsia, gestational hypertension, HELLP, gestational diabetes) * Body-Mass-Index (BMI) \< 18kg/m2 or \>40kg/m2

Design outcomes

Primary

Measure	Time frame	Description
Portal vein pulsatility fraction (percent)	single time-point at baseline	Portal vein pulsatility fraction (percent)

Secondary

Measure	Time frame	Description
Inferior vena cava diameter (mm)	single time-point at baseline	Inferior vena cava diameter (mm)
Inferior vena cava collapsibility index (percent)	single time-point at baseline	Inferior vena cava collapsibility index (percent)
Hepatic venous flow (cm/sec)	single time-point at baseline	Hepatic venous flow (cm/sec)
Right atrial and ventricular dimensions (cm)	single time-point at baseline	Right atrial and ventricular dimensions (cm)
Tricuspid Annular Plane Systolic Excursion (TAPSE) (mm)	single time-point at baseline	Tricuspid Annular Plane Systolic Excursion (TAPSE) (mm)

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026