Acute Respiratory Failure, Coronavirus Infection
Conditions
Keywords
coronavirus disease 2019, prone position
Brief summary
the purpose of this study to evaluate the effect of early awake PP (prone position)application on oxygenation and intubation requirement in patients with acute respiratory failure due to coronavirus disease 2019 pneumonia.
Detailed description
The first group (early prone position-EPP) created for our study was composed of patients who received PP at least 12 hours early (with the first 48 hours) with the oxygen support of the reservoir mask, and the second group (non-EPP ) patients who received oxygen with the reservoir mask but could not be applied early PP due to the patient's incompatibility or rejection. Conventional oxygen therapy applied to all patients was given with a reservoir mask, aiming at oxygen saturation 93% and above, at a flow rate of 6-15 L / min. Despite all the treatments, the patients who have a follow-up with a respiratory acidosis , oxygen saturation value below 93%, applied non invasive mechanical ventilation, in case of insufficient patient intubated and have invasive mechanical ventilation. In patients who had regression of glasgow coma scale during follow-up, orotracheal intubation was performed and invasive mechanical ventilation was performed.
Interventions
BEHAVIORALprone position
to lay in prone position at least 12 hour in a day at ICU
Sponsors
Sisli Hamidiye Etfal Training and Research Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who developed acute respiratory failure due to coronavirus disease 2019 pneumonia * received conventional oxygen therapy with reservoir mask oxygen at the stage of admission to the intensive care unit * older than 18 years old
Exclusion criteria
* patients with respiratory acidosis, * partial oxygen pressure/fraction of inspired oxygen ratio below 150, * Glasgow Coma Score (GKS) below 12 points, * hemodynamic instability, * primary pulmonary pathologies other than pneumonia (lung cancer, cardiopulmonary edema, carcinogen syndrome, etc.) * patients who underwent non-invasive mechanical ventilation(NIMV) or intubated from admission to intensive care, * those who underwent self prone position under 12 hours were not included in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| intensive care unit stay | up to 28 days | the duration of icu stay day |
| short term mortality | up to 28 days | mortality percent |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| blood gases | up to 24 hours | partial oxygen pressure: mmhg , partial carbondiocsit pressure mmhg |
Countries
Turkey (Türkiye)
Outcome results
None listed