Is Adipose Tissue a Reservoir for SARS-Cov2 Spread in Covid-19 Patients?

Is Adipose Tissue a Reservoir for SARS-Cov2 Spread?

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04427878

Acronym

TA/SARS-Cov2

Enrollment

Registered

2020-06-11

Start date

2020-08-03

Completion date

2020-09-09

Last updated

2024-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Covid-19 Patients

Brief summary

Resident cells of human adipose tissue express ACE2 and DPP4, receptors for SARS-Cov2. The hypothesis is that the virus may enter and spread in fat depots.

Interventions

PROCEDUREbiopsies of subcutaneous adipose tissue

Two 4mm punch biopsies of subcutaneous abdominal or thight adipose tissue

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Male or female ≥ 18 years old * Patients testing positive for Covid19 * Patients affiliated to social security * Signing of free and informed consent

Exclusion criteria

* Vulnerable persons (- minors, * adults under guardianship or curatorship, * pregnant women, * persons deprived of their liberty, * persons who do not master the French language)

Design outcomes

Primary

Measure	Time frame	Description
The presence of SARS-CoV2 in adipose tissue of Covid19 patients	Day 0	RT-qPCR for SARS-Cov-2 from RNAs and by immunodetection

Secondary

Measure	Time frame	Description
The expression of inflammatory cytokines in adipose tissue of Covid19 patients	Day 0	RT-qPCR for IL6

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026