Healthy
Conditions
Brief summary
This research study is about how daily activities, behaviors, and fitness affect the health and function of blood cells and their mitochondria, which are the powerhouses of the cells. These small mitochondria inside the cells make energy, and are very important for the health of the body.
Detailed description
Determine the impact of physical activity and obesity status on circulating cells mitochondrial function (e.g., fat vs. carbohydrates combustion capacity, total oxidative capacity, mitochondrial number and proton leak).
Interventions
None listed
Sponsors
Arkansas Children's Hospital Research Institute
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
8 Years to 10 Years
Healthy volunteers
Yes
Inclusion criteria
Ages 8-10 years Boys and girls All ethnicity All BMI
Exclusion criteria
severe persistent asthma exercise induced asthma autism spectrum disorder attention deficit hyperactivity disorder attention deficit disorder * Opposition defiant disorder * conduct disorder * epilepsy * chronic kidney disease * hormonal disease * autoimmune diseases * bleeding disorders * chronic infections * mental health disorder * Type 2 and Type 1 diabetes * Other pre-existing medical conditions or medications as determined by the investigators to affect the outcomes of interest
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Platelet mitochondrial respiration and its association with adiposity and peak aerobic capacity in children 8 to 10 years old. | 8 days | Platelet mitochondrial respiration from isolated platelets will be measured using a flux analyzer. Adiposity will be measured with dual X-ray absorptiometry, and peak aerobic capacity with an incremental cycle ergometer test. measure physical activity |
Countries
United States
Contacts
Primary ContactTonja C Nolen, MS
Backup ContactAudrey Martinez, MS, RD, LD
Outcome results
None listed