Arrhythmias, Cardiac, Hypocalcemia, Hypokalemia, Hypomagnesemia, Proton Pump Inhibitor Adverse Reaction, Seizures
Conditions
Brief summary
Use of proton pump inhibitors has been associated with hypomagnesemia. However, various case-control or prospective studies have found conflicting results with regards to proton pump inhibitors use and development of hypomagnesemia. Our aim was to evaluate the likelihood that proton pump inhibitors contributed to severe hypomagnesemia in a retrospective cohort of patients admitted with severe hypomagenesemia. We also aimed to look for risk factors leading to development of hypomagnesemia amongst users of proton pump inhibitors
Interventions
DRUGproton pump inhibitor use
Patients using long term proton pump inhibitor
Sponsors
Changi General Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
14 Years to 100 Years
Inclusion criteria
* Patients admitted with hypomagnesemia (cases) * Patients prescribed with proton pump inhibitors (controls)
Exclusion criteria
* Patients prescribed with less than three months duration of proton pump inhibitors (controls)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hypomagnesemia due to use with proton pump inhibitor | 2013 to 2016 | Number of patients with Hypomagnesemia related to use of proton pump inhibitor using Naranjo score |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Risk factors for Hypomagnesemia | 2013 to 2016 | Odds ratio of developing Hypomagnesemia with risk factors of age, gender, type of drug, dose of drug, chronic renal failure, use of diuretics |
| Hypocalcaemia | 2013 to 2016 | Number of patients developing hypocalcemia |
| Hypokalemia | 2013 to 2016 | Number of patients developing Hypokalemia |
Countries
Singapore
Outcome results
None listed