Effect of Progesterone Therapy on Traumatic Subarachinoid Haemorrhage on Clinical Outcome and Resistive Vasculer Indices of Middle Cerebral Artery Transcranial Doppler

Effect of Progesterone Therapy in Cases With Traumatic Subarachinoid Haemorrhage on Clinical Outcome and Resistive Vasculer Indices of Middle Cerebral Artery Transcranial Doppler

Status

UNKNOWN

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04426487

Enrollment

200

Registered

2020-06-11

Start date

2020-06-20

Completion date

2020-10-30

Last updated

2020-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic Brain Injury

Keywords

Progesterone, Transcranial doppler

Brief summary

Traumatic subarachinoid hemorrhage is associated with serious complications related to mortality . Delayed neuronal ischemia and rebleeding are most common and serious. Progesterone can delay both .

Detailed description

Progesterone is an neurosteroid that can help integrity of blood brain barrier . Traumatic subarachinoid hemorrhage disrupts this blood brain barrier facilitating post traumatic vasospasm and neuronal ischemia. Transcranial doppler can detect cerebral vasoconstriction through resistive vasculer indices

Interventions

DRUGProgesterone

Intramusculer progesterone

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Caregiver)

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Traumatic subarachinoid hemorrhage

Exclusion criteria

* History of malignency * History of cerebrovasculer stroke * Morbid obese

Design outcomes

Primary

Measure	Time frame	Description
Number of participants suffering neuronal infarction	2 months	Transcranial doppler

Countries

Egypt

Contacts

Primary ContactMina Raouf, MD

drmina2015@gmail.com01015752424

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026