Acute Kidney Injury, Sepsis
Conditions
Keywords
Acute Kidney Injury, Sepsis
Brief summary
Acute kidney injury (AKI) Diagnosis is based on rising creatinine. Intrarenal vasoconstriction occurs earlier and measuring flow resistance in the renal circulation (Renal Resistive Index (RRI)) could become part of vital organ function assessment using Doppler ultrasound. The aim of this study is to predict AKI in septic patients in ICU by measuring RRI on admission by comparing two groups of patients, first group with RRI of normal value (0.6-0.7) and the other group with high RRI more than 0.7 and both with normal renal function on admission.
Detailed description
Patients who have criteria of sepsis, with normal renal function on admission will undergo Renal Doppler Ultrasound examination to measure Renal resistive index. Patients will be divided into 2 groups: 1. Group (A) patients with renal resistive index between 0.6 and 0.7 (normal RRI). 2. Group (B) patients with renal resistive index more than 0.7 (high RRI).
Interventions
DIAGNOSTIC_TESTRenal Doppler Ultrasound
Measurement of Renal resistive index
Sponsors
Ain Shams University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Inclusion criteria
1. Patients who have criteria of sepsis on admission which include two or more of SIRS which include: (Temperature \>38°C or \<36°C, Heart rate \>90/min, Respiratory rate \>20/min or PaCO2 \<32mmHg (4.3kPa) and White blood cell count \>12000/mm3 or \<4000/mm3 or \>10% immature bands.) in addition to suspected or confirmed infection. 2. Patients who have normal renal function on admission.
Exclusion criteria
1. Currently recovering from an AKI at the time of inclusion and Renal impairment on admission. 2. Patients with obstructive renal failure, renal artery stenosis were excluded from this study. 3. Patients on chemotherapy and/or radiotherapy. 4. Pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence of AKI | 1 day at admission | incidence of AKI related to Renal resistive index. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| APACHE IV score | 1 day at admission | Acute Physiology and Chronic Health Evaluation scores. Score range (0 better - 286 worse) |
| SOFA score | 1 day at admission | Sequential Organ Failure Assessment (SOFA) score. Score Range (0 better - 24 worse) |
| APACHE III score | 1 day at admission | Acute Physiology and Chronic Health Evaluation scores. Score range (0 better - 299 worse) |
Countries
Egypt
Outcome results
None listed