Evaluation of Early Retinal Vascular Modifications After Endoscopic Endonasal Pituitary Surgery

Early Retinal Vascular Modifications After Endoscopic Endonasal Pituitary Surgery: The Role of OCT- Angiography

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04425954

Enrollment

Registered

2020-06-11

Start date

2019-01-01

Completion date

2019-03-31

Last updated

2020-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pituitary Adenoma

Brief summary

This study evaluates the retinal vascular features using optical coherence tomography angiography in patients that received endoscopic endonasal approach for the removal of an intra-suprasellar pituitary adenoma compressing the optic nerve.

Detailed description

To investigate the potential role of optical coherence tomography angiography in predicting the postoperative recovery of retinal vascular network of the optic disc in patients before and at 3 months after Endoscopic Endonasal Approach for the removal of an intra-suprasellar pituitary adenoma compressing the optic nerve. The optical coherence tomography angiography represents a novel and non-invasive diagnostic technique that allows a detailed analysis of retinal vascular features.

Interventions

PROCEDUREEndoscopic Endonasal Pituitary Surgery

Surgical treatment consisted of an endoscopic endonasal approach using a rigid 0-degree endoscope, 18 cm in length and 4 mm in diameter.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

45 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* age older than 45 years * diagnosis of pituitary adenoma * treatment-naïve with Endoscopic Endonasal Pituitary Surgery * absence of other neurological diseases * absence of vitreoretinal and vascular retinal diseases

Exclusion criteria

* age younger than 45 years * No diagnosis of pituitary adenoma * previous treatments with Endoscopic Endonasal Pituitary Surgery * presence of neurological diseases * presence of vitreoretinal and vascular retinal diseases

Design outcomes

Primary

Measure	Time frame	Description
Study of vessel density of the optic disc in patients underwent Endoscopic Endonasal Pituitary Surgery for the removal of an intra-suprasellar pituitary adenoma compressing the optic nerve.	48 hours	To evaluate the role of optical coherence tomography angiography in predicting the recovery of the vessel density of the optic disc after surgery, using optical coherence tomography angiography (OCTA). The parameter analyzed by OCTA was the vessel density of the optic disc (percent)

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026