Retinoblastoma
Conditions
Brief summary
As the survival of children with retinoblastoma in high income countries is higher than 95% including the bilateral forms this study hopes to improve the outcome in low income countries in Africa by improving early diagnosis and early implementation of this protocol of therapeutic recommendations for treatment.
Detailed description
In this study we will try to improve the outcome for children with stage II disease. It is hoped that we will be able to show that with early intervention correct early diagnosis the survival of these children is greatly improved. The collection of data in this observational study will allow us to show this improvement, by analysis of stage, treatment and outcome.
Interventions
OTHEROBSERVATIONAL
We will look at the outcome of the the children treated to see if the survival is improved when these therapeutic measures are followed.
Sponsors
French Africa Pediatric Oncology Group
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Inclusion criteria
* Unilateral intraocular Retinoblastoma (RB) * Unilateral extraocular intraorbital (RB) * Bilateral intraocular (RB) * bilateral intraocular (RB) on one side and extraocular but intraorbital on the other side.
Exclusion criteria
* Externalized tumor mass * massive extension to optic nerve up to optical channeltumor * intracranial extension leptomeninges * cerebral parenchyma * extension to regional lymph nodes and/or remote metastases. * cerebrospinal fluid involvement. * Trilateral RB * Incapacity to followed the whole treatement.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of cases with retinoblastoma in each participating hospital. | 10 years | Evaluation of the number of cases registered . |
| Number of cases with stage 2 disease | 10 years | Evaluation of the number of cases registered with stage 2 disease. |
| Feasibility of these therapeutic recommendations in an African setting | 10 years | Evaluate the application of these therapeutic recommendations |
| Evaluating the treatment given. | 10 years | Comparison of treatment given and recommended treatment. |
| follow up | 10 years | analysis of the number of children alive or dead after treatment |
Countries
Burkina Faso, Côte d’Ivoire, Democratic Republic of the Congo, Madagascar, Mali, Senegal
Contacts
CONTACTKARIM Mr ASSANI, Dr.
CONTACTBRENDA Ms MALLON, MSc
PRINCIPAL_INVESTIGATORFOUSSEYNI Mr TRAORE, Dr;
AMCC AND GFAOP
Outcome results
None listed