Obesity and Mortality of Critically Ill Patients With COVID-19

Obesity as a Risk Factor for Mortality of Critically Ill Patients With Coronavirus Disease 2019 (COVID-19): a Cohort Study of the First Wave in Nancy, France

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04425213

Acronym

COV-OB-ICU

Enrollment

250

Registered

2020-06-11

Start date

2020-05-12

Completion date

2020-05-26

Last updated

2020-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Comorbidities and Coexisting Conditions, COVID, Obesity, Severe Acute Respiratory Syndrome

Keywords

Mortality, Covid-19, Invasive mechanical ventilation, Obesity, Acute Respiratory Distress syndrome, Intensive Care Unit, Critically ill patient

Brief summary

Disproportionate impact of COVID-19 in patients with obesity is now well established. Obesity is associated with severe forms of COVID-19 and may be a risk factor of intensive care unit (ICU) admission. Obesity is associated with COVID-19 related hospital death in a large United Kingdom cohort study. However, there is a gap of knowledge on assessment of outcomes such as severity of Acute Respiratory Distress syndrome (ARDS), duration of hospitalisation and mortality in ICU. Moreover, an obesity survival paradox has been observed in patients with ARDS. This raises the question whether the obesity paradox has been broken by COVID-19. The investigators aim to explore risk factors of in-ICU death for patient with COVID-19, including obesity and other chronic diseases and to describe the clinical course and outcomes, including the management of acute respiratory failure and other intensive care management.

Detailed description

The investigators aim to report ICU mortality for patients according to BMI category and to describe the detailed ICU clinical course of illness : * Risk factors for ICU mortality : age, sex, baseline comorbidities * Causes of death * Risk factors for use of non invasive mechanical ventilation * Non-fatal outcomes * Ventilator-free days * ICU length of stay.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adult patients with COVID-19 pneumonia admitted to ICUs between February 27th and April 18th 2020. * Infection confirmed by reverse transcriptase polymerase chain reaction assay or radiologically by chest computed tomography scan

Exclusion criteria

* No weight or height measurement available in the medical files

Design outcomes

Primary

Measure	Time frame	Description
ICU mortality	through study completion, an average of 14 days	number of fatal cases

Secondary

Measure	Time frame	Description
Invasive mechanical ventilation	through study completion, an average of 14 days	number of patients with invasive mechanical ventilation
In-hospital mortality	through study completion, an average of 21 days	number of fatal cases

Countries

France

Outcome results