Renal Cell Carcinoma
Conditions
Brief summary
The aim of this study is to determine the utility of renal ultrasonography (US) in the detection of abdominal recurrences after definitive therapy for renal cell carcinoma (RCC) and compare the detection rate to that of cross-sectional imaging.
Interventions
DIAGNOSTIC_TESTUltrasonography
Abdominal Ultrasonography
Sponsors
University of Kansas Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Masking description
The sonographer for the additional ultrasound will be blinded as will be the blinded radiology who will compare the US to the most recent negative CT/MRI to determine if recurrence is visualized by US
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients must be 18 year of age or older. * Patients having undergone radical or partial nephrectomy for the indication of renal cell carcinoma. * Most recent imaging study must have been either computed tomography (CT) or magnetic resonance imaging (MRI).
Exclusion criteria
* Patients with pT4 disease (tumor invades beyond the Gerota fascia: including contiguous extension into the ipsilateral adrenal gland). * Patients with metastatic disease prior to time of surgery requiring systemic treatment. * Patients with another active cancer diagnosis requiring systemic treatment. * Patients with contrast allergies. * Patients with baseline chronic kidney disease (GFR \< 45 ml/min/1.73 m2).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Utility of Renal Ultrasonography (US) in the detection of abdominal recurrences | 4 weeks | Renal Cell Carcinoma (RCC) recurrence detection of ultrasonography in patients who have undergo definitive therapy for RCC compared to detection rate of cross-sectional imaging |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Radiation Burden | 5 years | Compare the average radiation exposure over 5 years for patients on current standard of care imaging surveillance for RCC, which consists of both ultrasound and cross-sectional imaging, to that of patients who would only receive cross-section imaging surveillance for RCC. This would yield overall increase in radiation burden for patients with RCC |
Countries
United States
Contacts
Primary ContactKatherine Glavin
Outcome results
None listed