Respiratory Physiology
Conditions
Keywords
diaphragm, ultrasound
Brief summary
The assessment of the work of the respiratory muscles is a fundamental clinical data in intensive care, especially to guide the management of patients requiring ventilatory support. This data is difficult to access in current practice. The reference technique to estimate the work of breathing (transdiaphragmatic pressure) is not feasible in clinical routine and evaluates only the respiratory work of the diaphragm, not that of the accessory muscles. The ultrasound technique of speckle tracking allows a fine and multidimensional analysis of the deformation of the respiratory muscles during the respiratory cycle. The investigators hypothesize that the analysis of the multidimensional deformation of the diaphragm at the level of the apposition zone can produce a robust and reproducible index, which is correlated with the work of breathing. The performance of this index will be compared to that of the thickening fraction of the diaphragm. On the other hand, the investigators will evaluate the feasibility of measuring the thickening of the accessory respiratory muscles (scalene and intercostal).
Detailed description
Fifteen healthy subjects will be equipped with a double-balloon esophagogastric tube and subjected to increasing and gradual loading of the respiratory system by a negative-pressure inspiration device. The respiratory work will be recorded continuously by measuring the transdiaphragmatic pressure (reference technique). The recording of the deformation of the diaphragmatic apposition zone by speckle tracking technique will make it possible to define a multi-dimensional deformation index of this muscular portion. The reproducibility and the repeatability of this index will be evaluated then this index will be compared to the reference technique, as well as to the fraction of thickening. The deformation of the accessory muscles will also be evaluated in a second step.
Interventions
OTHERdiaphragm ultrasound
respiratory loading
Sponsors
Centre Hospitalier Saint Joseph Saint Luc de Lyon
Study design
Observational model
CASE_ONLY
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteer (male or female) * Free and informed consent
Exclusion criteria
* known pregnancy, parturient or nursing mother * Under 18 years old * Age\> 45 years * Incapable major * Non-affiliation to the social security system * Any history of respiratory pathology * Any history of coagulation disorder or platelet function
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Coefficient of reproducibility | 1 hour | reproducibility and repetability measurments of strain (ε) and strain rate (ε') . |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| agreement between the strain and pressure time product of diaphragm (PTPdi) | 1 hour | Correlation between the strain and pressure time product of diaphragm (PTPdi) |
| agreement between the strain rate of the PTPdi | 1 hour | Correlation between the strain rate of the PTPdi |
| comparison of repeatability and reproducibility of the various ultrasound indices (TEE, TFdi, ε and ε '). | 1 hour | Comparison of repeatability and reproducibility of the various ultrasound indices (TEE, TFdi, ε and ε '). |
| Repeatability and reproducibility of the measurement of the deformation (ε) and the rate of deformation (ε ') of the accessory muscles (scalene then intercostal) subjected to variable inspiratory loads. | 1 hour | Repeatability and reproducibility of the measurement of the deformation (ε) and the rate of deformation (ε ') of the accessory muscles (scalene then intercostal) subjected to variable inspiratory loads. |
| Exploration of the link between the deformation of the accessory respiratory muscles by speckle tracking and the PTPdi | 1 hour | Coorelatin between strain of the accessory respiratory muscles and the PTPdi |
Countries
France
Outcome results
None listed