Knee Osteoarthritis
Conditions
Brief summary
Despite the past decade being dedicated to bone and joint disease, the incidence and prevalence rates of osteoarthritis continues to rise, and till date not curative treatment has been identified for the management of knee osteoarthritis. In terms of conservative management of knee osteoarthritis, pharmacological management has been the mainstay of treatment, however is associated with numerous adverse effects with prolonged use, and it is important to look into the non-pharmacological alternates for the management of knee osteoarthritis. Research has shown resistance exercise training to be the most effective non-pharmacological treatment option for the management of knee osteoarthritis, and the purpose of the current study is to determine if the addition of a non-pharmacological dietry supplement like creatine can amplify the beneficial effects of resistance exercise training in patients with knee osteoarthritis.
Interventions
Treadmill walking 5-10 min for warm up Strength training: (80% of 8RM) 3 times supervised exercise for 4 weeks Warm up (Self Paced walking for 10 minutes) leg press, leg extension, Sit to stand squat (mini squats) Stationary Cycling (Maximum Resistance as per patient tolerance till failure) 3 sets 8 reps 10-15 s rep rest interval 1-2 min set rest interval
OTHERHome Exercise Plan
2 sets of 10 repetitions/day of AROM isolated knee extension and knee flexion Isometric isolated knee extension and knee flexion Isometric terminal knee extension Sit to stand squat Isometric knee terminal extension
DEVICEElectrotherapy + Heating
Interferential Current therapy (2P), in combination with heating pad for 20 minutes
PROCEDUREJoint Mobilization
Tibio-femoral Anterior Glide Tibio-femoral Posterior Glide Patellofemoral Joint Mobilization
DIETARY_SUPPLEMENTCreatine Supplementation
Creatine Supplementation 20g/day for 1 week followed by 5 g/day for 3 weeks
Sponsors
Foundation University Islamabad
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Age 40-70 years * Knee OA with history not less than three months. * Radiological evidences of grade III or less on Kellgren classification. * Knee pain on VNRS no more than 8/10
Exclusion criteria
* Neuromuscular conditions that may lead to fatigue such as multiple Sclerosis * Signs of serious pathology (e.g., malignancy, inflammatory disorder, infection). * History of trauma or fractures in lower extremity. * Signs of lumbar radiculopathy or myelopathy. * History of knee surgery or replacement. * Patients on intra-articular steroid therapy within two months before the commencement of the study. * Impaired skin sensation. * Impaired renal function
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Knee Isometric Muscle Strength | 2 weeks | Knee Isometric Muscle Strength will be quantified by using Modified Sphygmomanometer Dynamometer |
| 5 repetition sit to stand test | 2 weeks | Time will be measured to perform 5 repetitions of sit to stand activity. Lesser time means a better score. |
| Knee Pain: Visual Analogue Scale | 2 weeks | Visual Analogue Scale was used to measure pain scoring from 0-10 cm on a horizontal 10cm line. A greater score reflects higher pain intensity. |
| Knee Range of Motion | 2 weeks | Knee Range of Motion will be quantified by using Gonimeter |
| Six Minute Walk Test | 2 weeks | Six Minute Walk Test will be used to quantify walking related performance fatigability, walking distance and walking speed. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body Composition | 2 weeks | Body Composition was measured via bioelectrical impedance analysis. A greater Phase angle reflects better cellular integrity and smaller phase angle reflects poorer cellular integrity. |
| Fall Risk | 2 weeks | Fall risk will be quantified by using Biodex balance System |
| Knee Injury and Osteoarthritis Outcome Score (KOOS) | 2 weeks | Knee Injury and Osteoarthritis Outcome Score (KOOS) to measure physical function and quality of life. A greater score on Knee Injury and Osteoarthritis Outcome Score reflects good prognosis and outcome and a lower score shows poor prognosis and outcome. the score for Knee Injury and Osteoarthritis Outcome Score is reported in the form of percentage i.e. 0-100%. |
Countries
Pakistan
Outcome results
None listed