Renal Failure, Chronic Kidney Diseases, Failure,Kidney, Renal Artery Stenosis, Fibrosis, Complications
Conditions
Keywords
3D Ultrasound, US elastography, US MFI, Ultrasound, MRI, CT
Brief summary
This study evaluates the role of advanced US technology in assessing renal transplants as screening tools such as 3D Ultrasound, Ultrasound SWE, and MFI besides current ultrasound conventional metheds.
Detailed description
This study will focus on monitoring renal after transplantation using all US advanced technology. Aim one will concentrate on the 3D US in assessing artery stenosis (TRAS) compared to the gold standard. Aim two focuses on will concentrate on Ultrasound elastography in assessing renal stiffness. Aim three will compare US colour modes such as PD, CD and MFI to assess renal perfusion in three groups. Duration: 18 Months; participants will have a patient information sheet; once they are happy to participate, consent will be obtained. Study data will be entered into a database encrypted and stored in the department. Only the study principal investigator (PI) will know the study database password.
Interventions
DEVICE3D imaging
The study will focus on the accuracy of ultrasound technology in assessing renal transplants. The entire assessment should not take more than 25 minutes.
Sponsors
Imperial College London
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients ≥ 18 years. * Tx patients. * Gender.
Exclusion criteria
* Prisoners. * Patients \< 18 years. * Pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Peak systolic velocity ratio (PSVR). | 12 weeks | High velocity flow at the stenosis site divided by a reference velocity (normal before stenosis) |
| Resistive Index (RI). | 12 weeks | An RI less than 0.7 to 0.8 is considered normal, more than that it is indicator of transplant dysfunction. |
| Peak systolic velocity (cm/s). | 12 weeks | Pean of the blood flow velocities in the artery/ vein peak systolic velocity ≥200 cm/s velocity difference between pre- and post-stenotic segments of 2:1 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Volumetric stenosis. | 12 weeks | Plaque volume is calculated automatically with the aid of software with a package of 3D laptop. |
| 3D GSM. | 12 weeks | Plaque volume is calculated automatically with the aid of software with a package of 3D laptop. |
Countries
United Kingdom
Outcome results
None listed