Knee Osteoarthritis
Conditions
Brief summary
Osteoarthritis is the 11th highest contributor to disability world wide. In terms of conservative management of patients with knee osteoarthritis, Resistance exercise has been shown to be an effective intervention for reducing pain and cartilage degeneration and improving muscle strength, joint biomechanics and physical functioning. But, research shows that co supplementation can further augment the effects of resistance exercise. However, it is imperative to point out that the existing evidence is majorly focused on the individual effects of resistance exercise training and non-pharmacological supplementation, and is still deficient in the effects of co-supplementation in addition to resistance exercise training in patients with knee osteoarthritis.
Interventions
3 times supervised exercise for 4 weeks Warm up (Self Paced walking for 10 minutes) leg press (8-12 RM) leg extension (8-12 RM) Sit to stand squat (with weight) Stationary Cycling (Maximum Resistance as per patient tolerance till failure)
OTHERHome Exercise Plan
2 sets of 10 repetitions/day of 1. AROM isolated knee extension and knee flexion 2. Isometric isolated knee extension and knee flexion 3. Isometric terminal knee extension 4. Sit to stand squat terminal extension as Home Exercise Program (HEP). (Iwamoto J et al, 2007)
DEVICEElectrotherapy + Heating
Iinterferential Current therapy (2P), in combination with heating pad for 20 minutes
PROCEDUREJoint Mobilization
1. Tibio-femoral Anterior Glide 2. Tibio-femoral Posterior Glide 3. Patellofemoral Joint Mobilization
DIETARY_SUPPLEMENTCreatine Supplementation
Creatine Supplementation 20g/day for 1 week followed by 5 g/day for 3 weeks
DIETARY_SUPPLEMENTGlucoseamine/ Chondritin Sulfate Supplementation
Glucoseamine/ Chondritin Sulfate Supplementation (500mg+400mg/day)
Sponsors
Isra University
Foundation University Islamabad
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Age 40-70 years * Knee OA with history not less than three months. * Radiological evidences of grade III or less on Kellgren classification. * Knee pain on VNRS no more than 8/10
Exclusion criteria
* Neuromuscular conditions that may lead to fatigue such as multiple Sclerosis * Signs of serious pathology (e.g., malignancy, inflammatory disorder, infection). * History of trauma or fractures in lower extremity. * Signs of lumbar radiculopathy or myelopathy. * History of knee surgery or replacement. * Patients on intra-articular steroid therapy within two months before the commencement of the study. * Impaired skin sensation. * Impaired renal function
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Six Minute Walk Test | 4 weeks | Six Minute Walk Test will be used to quantify walking related performance fatigability, walkind distance and walking speed. |
| Knee Pain: Numeric Pain Rating Scale | 4 weeks | Knee Pain will be quantified by using Numeric Pain Rating Scale |
| Knee Range of Motion | 4 weeks | Knee Range of Motion will be quantified by using Gonimeter |
| Knee Isometric Muscle Strength | 4 weeks | Knee Isometric Muscle Strength will be quantified by using Modified Sphygmomanometer Dynamometer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Knee Injury and Osteoarthritis Outcome Score (KOOS) | 4 weeks | The KOOS is self-administered and assesses five outcomes: pain, symptoms, activities of daily living, sport and recreation function, and knee-related quality of life. |
| Body Composition | 4 weeks | Body Composition will be quantified by using Bioelectrical Impedance |
| Fall Risk | 4 weeks | Fall risk will be quantified by using Biodex balance System |
| Postural Stability | 4 weeks | Postural Stability will be quantified by using Biodex balance System |
Countries
Pakistan
Contacts
Primary ContactMuhammad Osama, PhD*
Outcome results
None listed