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Usefulness of Cephalometry in the Second and Third Trimester of Pregnancy in the Diagnosis of Fetal Microretrognathia

Usefulness of Cephalometry in the Second and Third Trimester of Pregnancy in the Diagnosis of Fetal Microretrognathia : Prenatal Cephal

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04422067
Enrollment
68
Registered
2020-06-09
Start date
2019-05-01
Completion date
2019-09-30
Last updated
2020-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pierre Robin Sequence

Keywords

with one or more fetuses suffering from a microretrognathia, Cephalometry, Prenatal Diagnosis, Facial angles, Fetal echography, Microretrognathia, diagnosed prenatally

Brief summary

Congenital retrognathia, with or without Pierre Robin Sequence (PRS), is a rare anomaly which can be associated with chromosomal abnormalities. Respiratory and feeding consequences can be present at birth. After birth, the diagnosis of retrognathia is based on the clinical examination. Cephalometry can be used to complete the diagnosis. Several authors have proposed the use of objective quantitative ultrasound parameters for the antenatal screening of PRS. In our study, the investigators evaluated fetal cephalometry. The aim First, the investigators studied the inter- and intra-observer reproducibility of cephalometry. Second, the investigators established reference values for antenatal cephalometry in normal fetuses. Third, the investigators compared the diagnostic performance of cephalometry and the other angles described in the literature for the diagnosis of retrognathia.

Interventions

OTHERFetal cephalometry

Fetal cephalometry

Sponsors

University Hospital, Montpellier
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 44 Years
Healthy volunteers
No

Inclusion criteria

* Pregnant patient (Aged \>18years old) * with one or more fetuses suffering from a microretrognathia * diagnosed prenatally * integrated into a Pierre Robin Sequence

Exclusion criteria

* Uncvertain diagnosis * Absence of 3D rendering volume

Design outcomes

Primary

MeasureTime frameDescription
Reproducibility of cephalometryDuring ultrasoundReproducibility of cephalometry

Secondary

MeasureTime frameDescription
Perfomance of several angle to diagnose retrognatismDuring ultrasoundPerfomance of several angle to diagnose retrognatism

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026