Acute Ichemic Stroke, Brain Ischemia
Conditions
Keywords
Stroke, Blood Brain Barrier, Ischemia, Thrombus, Interventional Neuroradiology
Brief summary
Analysis of peri clot blood collected at the acute phase of stroke in order to understand physiopathological mechanisms involved in the cerebrovascular damage
Detailed description
It has been shown that immune cells accumulate around the clot at the acute phase of stroke. Leukocytes and their specific chemokines and cytokines regulation may impact cerebrovascular integrity.
Interventions
OTHERAnalysis of the clot
Blood sampling at the site of intracranial occlusion during Mechanical Thrombectomy
Sponsors
Genomic Institute of Montpellier
University Hospital, Montpellier
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
1. Over 18 years of age, 2. Non-dependent for activities of daily living prior to the onset of the MI (Modified Rankin Score \>2) 3. Having an occlusion of a large arterial trunk proven by imaging (angio-MRI or angio-scanner).
Exclusion criteria
1. Patients initially admitted but for whom endovascular treatment will not finally be performed (re-infusion, catheterization failure...) will be excluded from the study. 2. Major patients under guardianship or curatorship or patients deprived of liberty
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metalloproteinase 9 quantification | 60 months |
| Metalloproteinase 2 quantification | 60 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cytokines levels | 60 months | Proteomic analysis of cytokines IL-1β, TNF-α, IL-6 |
Countries
France
Contacts
Primary ContactCyril DARGAZANLI, MD MSc
Backup ContactVincent COSTALAT, MD PhD
Outcome results
None listed