Keratitis
Conditions
Keywords
Corneal Ulcer
Brief summary
This is a multiple site observational study that will review patient features (clinical and morphologic) over a 90 day period during care of participants with microbial keratitis with presence of clinically significant ≥2mm stromal infiltrate compared with participants with other forms of keratitis.
Detailed description
The primary objective of this study is to determine associations between participant features (clinical and morphologic) and best corrected visual acuity at Day 90. Imaging, focused on slit lamp photography and supplemented by other imaging markers will be collected for review. A medical record review at one year following participants initial visit will record any corneal procedure and visual acuity testing that occurred during this window. Participants will complete demographic, clinical, and standardized health surveys.
Interventions
DIAGNOSTIC_TESTVisual Acuity
Best corrected visual acuity utilizing the Snellen method
Sponsors
National Eye Institute (NEI)
University of Michigan
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Cases- microbial keratitis (bacterial or fungal) with presence of clinically significant ≥2mm stromal infiltrate * Controls- Inflammatory, viral, Acanthamoeba, or other keratitis
Exclusion criteria
* Pregnancy * Prior incisional corneal surgery * No light perception vision * Corneal perforation or impending perforation * Inpatient status * Institutional status * Cognitively impaired * Prisoner
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual Acuity | 90 day follow up | Visual Acuity |
Countries
India, United States
Outcome results
None listed