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Brugada Ablation of VF Substrate Ongoing MultiCenter Registry

Brugada Ablation of VF Substrate Ongoing MultiCenter Registry

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04420078
Acronym
BRAVO
Enrollment
159
Registered
2020-06-09
Start date
2017-07-01
Completion date
2023-12-01
Last updated
2024-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brugada Syndrome

Brief summary

Current treatment of high-risk Brugada Syndrome (BrS) patients (pts) with recurrent VF is limited. Catheter ablation (CA) has been performed for BrS but a large study with long-term outcomes of CA in BrS ablation are lacking.

Detailed description

Brugada syndrome (BrS) patients who undergo BRS substrate ablations from tertiary centers for catheter ablations of complex arrhythmias from three continents - Asia, Europe and North America - are registered in a common database. The investigators exclude patients who were lost to follow up in the outpatient clinic.

Interventions

PROCEDURECatheter Ablation

Ventricular fibrillation substrate

Sponsors

University Hospital, Bordeaux
CollaboratorOTHER
University of Tsukuba
CollaboratorOTHER
University of London
CollaboratorOTHER
University of Amsterdam
CollaboratorOTHER
Ogaki Municipal Hospital
CollaboratorUNKNOWN
Indiana University
CollaboratorOTHER
Taipei Veterans General Hospital, Taiwan
CollaboratorOTHER_GOV
Zhejiang University
CollaboratorOTHER
Pacific Rim Electrophysiology Research Institute
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* Symptomatic Brugada Syndrome patients who had undergone catheter ablation of the arrhythmogenic substrates.

Exclusion criteria

* Patients who will not commit to regular follow up.

Design outcomes

Primary

MeasureTime frameDescription
Death3 yearsExpiration, unrelated to procedure
ICD Therapy for VT/VF3 yearsElectrical therapy delivered through device for termination of VF episodes

Secondary

MeasureTime frameDescription
Inappropriate ICD Therapy3 yearsCaused by lead sensing or programming errors
Normalization of Brugada ECG pattern3 yearsECG pattern is normal sinus rhythm after catheter ablation

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 9, 2026