Nutritional Requirements
Conditions
Keywords
nutrient, public nutrition, nutrition related diseases, nutrition epidemiology
Brief summary
Iodine is one of essential micronutrient for human, both iodine deficiency and excess will be harmful for human health. Children is the susceptible population to iodine nutrition, and studies show that even mild iodine deficiency would affect the growth and development of children, so it is urgent to identify the dietary recommended nutrient intake (RNI) of iodine for children to guide children scientifically and safely supplement iodine. There are few studies about the dietary recommended nutrient intake (RNI) of iodine in children, and present data are old and outdated.
Detailed description
Based on the investigators'previous study on upper safe level of iodine on children from areas with high iodine in drinking water, this study will conduct an epidemiological study on 600 children living in areas with high water iodine content but the actual iodine content in participants' drinking water is not so high, while no supply of iodized salt. Meanwhile, in order to get iodine dietary recommended nutrient intake (RNI) values of children. The investigators will conduct a iodine balance experiment on children with sufficient iodine nutrition. We will randomly select thirty healthy students for a three-day iodine balance experiment from the cross-sectional study. The investigators will use the regression model to obtain an iodine intake value when children atzero iodinebalance. Combine the study at population and individual level, the investigators will obtain data on dietary recommended nutrient intake (RNI) of iodine for Chinese children, to properly guide children iodine supplementation to avoid iodine deficiency, which also will provide data for the update of Chinese dietary reference intakes of iodine.
Interventions
OTHERno intervention
Natural exposure of iodine.
Sponsors
Shandong Institute for Endemic Disease Control and Research
Tianjin Medical University
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
7 Years to 11 Years
Healthy volunteers
Yes
Inclusion criteria
Normal body mass index and thyroid function have not been treated for thyroid disease have not used amiodarone and other drugs (including iodine supplements) during the investigation have no major diseases and family history have lived in the local area for more than 5 years
Exclusion criteria
Long-term low-protein long-term low-heat energy malnutrition
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fecal iodine excretion | 2 weeks | μg/day |
| urinary iodine concentration | 2 weeks | μg/L |
| free triiodothyronine | 2 weeks | pmol/L |
| water iodine intake | 2 weeks | μg/day |
| diet iodine intake | 2 weeks | μg/day |
| salt iodine concentration | 2 weeks | μg/L |
| free thyroxine | 2 weeks | pmol/L |
| thyroid-stimulating hormone | 2 weeks | mIU/L |
| thyroperoxidase antibody | 2 weeks | IU/mL |
| thyroglobulin antibody | 2 weeks | IU/mL |
| urinary iodine excretion | 2 weeks | μg/day |
Countries
China
Outcome results
None listed