Analysis of Breath Volatile Organic Compounds After Dyspnea Induced in the Healthy Subject.

Analysis of Breath Volatile Organic Compounds After Dyspnea Induced in the Healthy Subject, by a Threshold Inspiratory Load and During a Maximal Breath Holding.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04418973

Acronym

Volatopnee

Enrollment

Registered

2020-06-05

Start date

2020-09-07

Completion date

2020-10-14

Last updated

2020-10-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Subjects

Keywords

Volatolom, Volatile organic compounds (VOCs), dyspnea, electronic nose, mass spectrometry

Brief summary

The dyspnea is a common symptom in patients with many respiratory diseases particularly chronic obstructive airway diseases, but also cardiovascular pathologies, obesity, or also in the deconditioned healthy subjects. Called volatolom corresponds to the set of volatile organic compounds (VOCs) contained in exhaled air. The analysis of volatolom can be done either by the methods based on mass spectrometry which allows the identification of each VOC in the exhaled air or by the use of electronic noses which are more simple to use, less specific and produce a quantitive signal change based on pattern recognition algorithms providing a global profile of the VOC without identifying them. The aim of the study is to determine whether the analysis of VOCs in exhaled air would identify biomarkers related to the intensity and type of experimental dyspnea.

Interventions

OTHERVOCs analysis in exhaled air

using an electronic nose and a mass spectrometry

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* healthy subject * no dyspnea * non smoking or daily smoking more than 5 years packs * perfect knowing of the French language * the consent form signed * affiliated to a health insurance plan

Exclusion criteria

* chronic disease * history of asthma or Chronic obstructive pulmonary disease (COPD) * personal or family atopy * cannabis use * electronic cigarette * medication except contraception * pregnant woman * without liberty or guardianship

Design outcomes

Primary

Measure	Time frame	Description
Comparison of variation of volatile organic compounds profiles in exhaled air during dyspnea and normal breathing.	at the only one study visit: around 2 hours	Comparison of variation in VOC profiles in exhaled air of healthy subjects, over 2 types of dyspnea (inspiratory load and breath holding) relative to VOC profiles during normal rest ventilation. The VOC will be identified by their molecular mass (by the mass spectrometry) and the variations in the sensors properties of the electronic noses producing a quantitive signal change based on pattern recognition algorithms.

Secondary

Measure	Time frame	Description
Comparison of variation of volatile organic compounds profiles in exhaled air between the 2 types of dyspnea.	at the only one study visit: around 2 hours	Comparison of variation of volatile organic compounds profiles in exhaled air between the 2 types of dyspnea (inspiratory load and breath holding).The VOC will be identified by their molecular mass (by the mass spectrometry) and the sensor deflection (by an electronic nose).
Correlation between the intensity of the affective component of the dyspnea and the variation of VOC profiles.	at the only one study visit: around 2 hours	Correlation between the results of 2 questionnaires (affective multidimensional dyspnea and affective visual analogue scale) and the VOC profiles, in each of the 2 types of dyspnea.The VOC will be identified by their molecular mass (by the mass spectrometry) and the sensor deflection (by an electronic nose).
Correlation between the intensity of the sensory components of the dyspnea and the variation of VOC profiles.	at the only one study visit: around 2 hours	Correlation between the results of 2 patient sensory questionnaires (sensory multidimensional dyspnea and sensory visual analogue scale) and the VOC profiles of dyspnea.The VOC will be identified by their molecular mass (by the mass spectrometry) and the sensor deflection (by an electronic nose).
Comparison of VOC profiles in exhaled air according to smoking status.	at the only one study visit: around 2 hours	Comparison of VOC profiles in exhaled air of healthy subjects, in each of the 2 types of dyspnea smokers or non smokers. The VOC will be identified by their molecular mass (by the mass spectrometry) and the sensor deflection (by an electronic nose).

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026