Barlow Disease (BD), Mitral Insufficiency
Conditions
Keywords
mitral annuloplasty, mitral valve repair, mitral annulus, coaptation of mitral leaflets
Brief summary
Barlow disease (BD) is a common cause of mitral insufficiency. In 2012 the University Hospital of Basel started to perform a simplified mitral valve repair technique in BD just by implanting an annuloplasty-ring. It is hypothesized that the major mechanism of the valvular insufficiency in Barlow disease is a deformation of the left ventricle and the posterior mitral annulus, causing its aberrant displacement during the systole towards posterior and basal and thus impairing the coaptation of the leaflets. This prospective individual MRI study is to investigate the ventricle and the mitral annulus pre- and postoperatively for detailed analysis.
Interventions
DIAGNOSTIC_TESTMagnetic resonance imaging (MRI)
MRI pre- and postoperatively for detailed analysis of the ventricle and the mitral annulus. The first MRI will be performed on the admission day before surgery. The second MRI will be performed during the hospital stay, between 3 and 7 days after the operation. The MRI images are interpreted through a specialized cardiologist and radiologist.
Sponsors
University Hospital, Basel, Switzerland
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* identified Barlow disease suffering from significant mitral insufficiency with indication to surgery
Exclusion criteria
* Active endocarditis or any other etiology of mitral insufficiency else than Barlow disease * Inability to perform a cardiac MRI (e.g., metallic implants, claustrophobia) * Pregnancy * Inability to give consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in anatomical structures by MRI | The first MRI will be performed on the admission day before surgery. The second MRI will be performed during the hospital stay, between 3 and 7 days after the operation. | Change in anatomical structures by MRI: distance (mm) between the mitral annulus and the cardiac apex during the cardiac cycle before and after surgical correction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| function of the mitral valve by echocardiography | during the hospital stay, between 3 and 7 days after the operation and at cardiological follow-up over the first 3 months. | association between reduction of movement of the posterior annulus and the function of the valve after surgery (i.e. its residual insufficiency (0 = absent, 1 = mild, 2 = moderate, 3 = severe)). Evaluated with echocardiography as it is routinely performed in cardiac surgery. |
Countries
Switzerland
Contacts
Primary ContactMartin Grapow, Prof. Dr. med.
Backup ContactThibault Schaeffer
Outcome results
None listed