Covid 19
Conditions
Brief summary
The RT-PCR on rhino-pharynge sampling highlights the genetic material of the virus and indicates that a subject is infected with SARS-CoV-2. This test can be in about 30% of false negative cases, it does not allow to date the infection, nor to predict the asymptomatic, mild, moderate or severe evolution of the disease. In terms of public health, we need 1/ to better understand the chronology of the immune response to the virus in the general population and in contacts of index cases; 2/ To know which characteristics of the immune response are protective of future reinfections. Finally, in symptomatic subjects, we need biomarkers that predict the evolutionary mode of the disease (moderate vs. severe form).
Interventions
OTHERpatients COVID 19
Exposure to SARS-Cov2 but no symptoms (patient's family, medical staff) and General population (volunteers not exposed to SARS-Cov2)
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
COVID-19 patients will be selected in the 4 participating centres Contact subjects and healthy volunteers will be selected only in the coordinating centre (Centre Hospitalier Universitaire de Nice)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age ≥ 18 years, * patients with confirmed SARS-Cov2 infection (RT PCR positive) * or patients suspected (evocative chest scanner) * OR patients exposure to SARS-CoV2 but no symptoms (patient's family, caregivers) * OR patients Non exposure to SARS-Cov2 volunteer subjects (general population)
Exclusion criteria
* pregnant or breastfeeding female
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| IgA specific cells of SARS | At 7 days | Proportion of subjects with IgA-specific cells of SARS-CoV-2's Spike 1 protein at inclusion and 7 +/-2 days later |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| OMS progression scale | At 7 days | The scale is 7-point ordinal. |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORLEROY Sylvie
CHU de Nice, pneumologie
Outcome results
None listed