Obesity
Conditions
Brief summary
The addition of ultrasound-induced adipose tissue cavitation (UATC) at the level of the abdominal subcutaneous adipose tissue may seem relevant as an additive treatment option to exercise intervention in individuals with obesity. However, whether individuals with obesity who participate in an exercise intervention and additionally undergo UATC, are more likely to develop a metabolically healthy phenotype, as opposed to subjects with obesity undergoing exercise training or UATC only, remains to be studied. Therefore, the first aim of this study is to examine the impact of combined UATC during exercise intervention on abdominal subcutaneous and whole-body adipose tissue mass, quality of life and cardiometabolic risk in individuals with abdominal obesity.
Interventions
OTHERExercise training intervention with ultrasound induced adipose tissue cavitation
Exercise training intervention with ultrasound induced adipose tissue cavitation
OTHERExercise training intervention without ultrasound induced adipose tissue cavitation
Exercise training intervention with ultrasound induced adipose tissue cavitation
Sponsors
Hasselt University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* male/female (1:1), * age 18-65 y, * abdominal obesity (waist circumference \>102cm or \>88cm) -
Exclusion criteria
* involvement in dietary or exercise intervention in the last year, * intake of any medication, * clinically diagnosed diseases (cardiovascular disease, hypertension, venous thromboses blood diseases, presence of a pacemaker/defibrillator, brain or nervous system diseases, kidney, thyroid or liver disease, chronic inflammatory diseases, cancer, osteoporosis and epilepsy). * Persons with a pregnancy, * a recent bone injury or the presence of a metal prothese
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| oral glucose tolerance test | Baseline | glucose and insulin levels at 0, 15, 30, 45, 60, 90 and 120 min post glucose load |
| kidney function | Baseline | urea, creatinine |
| inflammation | Baseline | CRP |
| Bloodpressure | Baseline | systolic and diastolic blood pressure |
| DEXA scan | baseline | Body composition (fat mass, fat free mass, android and gynoid fat mass), clinical measures (waist circumference, hip circumference, weight, height) |
| Fasting blood sample | Baseline | (glycated haemoglobin) |
| lipid profile | Baseline | total LDL, HDL, triglycerides |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| SF-36 questionaire | Baseline | Quality of Life questionaire, a 36-item, patient-reported survey of patient health. The SF-36 is a measure of health status |
| Food intake | Baseline | 3-day food diary |
| Overall physical fitness | Baseline | Maximal oxygen uptake (during cardiopulmonary exercise testing) |
Countries
Belgium
Outcome results
None listed