Diabetes, Gestational, Pregnancy Diabetic
Conditions
Brief summary
The primary objectives of the proposed project are to assess the long-term effects of prenatal exposure to gestational diabetes or diabetes on the maturation and health of the offspring. In addition, the long-term changes on the health of the affected mothers will be investigated, taking into account the metabolic adjustment during index pregnancy. The expected results will help to establish possible prevention strategies to fight the epidemic of non-communicable diseases for the offspring and the mothers.
Detailed description
Investigation of the long-term outcome of mother-child pairs after diabetic pregnancies and a comparison group regarding metabolic, cardiovascular, neurocognitive and reproductive long-term changes as a function of the course of pregnancy and metabolic control
Interventions
OTHERBasic data collection (online survey or written form)
Basic data collection is carried out by means of a questionnaire that participants can fill in outside the study centre. It contains questions about the current life situation, sleep and activity behaviour.
OTHERPhysical examination
The physical examination takes place at the study centre and includes the measurement of height, current weight and body fat, as well as the recording of heart and circulation parameters (e.g. blood pressure measurement or determination of vascular health by means of ultrasound). General metabolic and hormonal parameters are analysed by means of a blood sample. In addition, a sugar test for diabetes diagnosis will be carried out.
BEHAVIORALPsychometric examination
Psychometric examination is carried out at the study centre with the help of a RIAS (Reynolds Intellectual Assessment Scales and Screening) test.
DIAGNOSTIC_TESTRecording of the adrenergic stress reaction (saliva test)
The adrenergic stress reaction is recorded by a saliva test.
Sponsors
Jena University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* For the pilot project: Initial participation in the preliminary study * Written Informed Consent * Singleton pregnancies * Delivery at the University Hospital Jena
Exclusion criteria
* Severe physical and mental illness * Patients who refuse to participate in the study or drop out * Premature birth, i.e. birth of the child \<37/0 weeks of gestation * Serious pregnancy complications * Prenatally known serious malformations
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Metabolic health | 1 day examination at the study centre | effects on metabolic health such as glucose tolerance disorders and diabetes mellitus, obesity and metabolic syndrome (mothers and children) |
| Neurocognitive development | 1 day examination at the study centre | effects on neurocognitive development, mental health and adrenal and autonomic stress reactivity (mothers and children) |
| Cardiovascular and vascular health | 1 day examination at the study centre | effects on cardiovascular and vascular health of blood pressure regulation and endothelial function (mothers and children) |
| Maturation of the gonadal regulation | 1 day examination at the study centre | maturation of gonadal regulation, pubertal development and reproductive health (children) |
Countries
Germany
Outcome results
None listed