Spontaneous Coronary Artery Dissection
Conditions
Keywords
Spontaneous coronary artery dissection, SCAD
Brief summary
The study will investigate the clinical features, acute management and follow up of patients affected by spontaneous coronary artery dissection
Detailed description
Spontaneous Coronary Artery Dissection is now being increasingly studied as it is getting more and more relevant as a cause of ACS. Its management is currently a matter of debate due to the absence of RCT and even the trigger events related to this kind of infarction are still unclear. Notably, the benefits from the use of the antiplatelet medications that prolong bleeding time for a condition whose primary pathophysiology may be an intramural bleed are under discussion. Hence, the targets pursued by our study may be essentially distinguished in five main points: 1. To assess the characteristics of SCAD patients highlighting the predisposing and precipitating factors related to the acute event 2. To analyze clinical presentation and management of spontaneous coronary dissections in terms of therapeutic approach in the acute phase (conservative therapy vs revascularization) 3. To evaluate the incidence of SCAD recurrence and of major adverse cardiovascular events (MACEs) at follow-up 4. To analyze the impact of a single antiplatelet therapy (SAPT) over the dual one (DAPT) along with the impact of different P2Y12i regimens on acute and long-term prognosis 5. To evaluate impact of different angiographic SCAD type on outcome
Interventions
None listed
Sponsors
San Luigi Gonzaga Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Consecutive patients with a novel diagnosis of Spontaneous Coronary Artery Dissection (SCAD)
Exclusion criteria
* Age \<18 year old or inability to provide Informed Consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Major Cardiovascular Cardiac Events (a composite of all-cause of death, non-fatal Myocardial Infarction (MI) and any unplanned revascularization either percutaneous or surgical) | 12 months | Major Cardiovascular Cardiac Events occurring within 12 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| all-cause of death | 12 months | all-cause of death |
| non-fatal Myocardial Infarction (MI) | 12 months | non-fatal Myocardial Infarction (MI) |
| any unplanned revascularization either percutaneous or surgical | 12 months | any unplanned revascularization either percutaneous or surgical |
Other
| Measure | Time frame |
|---|---|
| Major Cardiovascular Cardiac Events (a composite of all-cause of death, non-fatal Myocardial Infarction (MI) and any unplanned revascularization either percutaneous or surgical) in Medical treatment vs PCI treated SCAD | 12 months |
| Major Cardiovascular Cardiac Events (a composite of all-cause of death, non-fatal Myocardial Infarction (MI) and any unplanned revascularization either percutaneous or surgical) in different angiographics SCAD type. | 12 months |
| Major Cardiovascular Cardiac Events (a composite of all-cause of death, non-fatal Myocardial Infarction (MI) and any unplanned revascularization either percutaneous or surgical) in Single vs Double Antiplatelets therapies in conservatively treated SCAD | 12 months |
Outcome results
None listed