Diffuse Traumatic Cerebral Edema
Conditions
Keywords
Progesterone, brain tumor, Neuronal biopsy
Brief summary
Neuronal injury is evident in elective craniotomy for space occupying lesions. Surgical trauma and mechanichal impact of the tumor causes neuronal injury. Neurosreroid progesterone is a neurotransmittern , trail to use in abolishing neurotoxcicty
Detailed description
Progesterone is a natural neurosteroid that we are trying to use to impede both direct neuronal injury cauesd by and indirectly by surgical trauma. Progesterone can decreas vasogenic brain oedema. Our primary outcome is to ameliorate microscopic cytoplasmic injury and decrease brain oedema exploited by biopsy from brain tumor interface. Exclusion criteria demonstratd as refusal to participate in the trial , emergency craniotomy, recurrent brain tumor.
Interventions
DRUGProgesteron
intramusculer progesterone
Sponsors
Minia University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* All elective brain tumors elligible for craniotomy
Exclusion criteria
* Refusal to participare * Emergency craniotomy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants With craniotomy-Related Adverse Events | 3 months | Degree of microscopic cellular injury and brain odema in brain biopsy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants with neuronal deficit | 2 months | Sensory, motor or autonomic dysfunction |
Countries
Egypt
Contacts
Primary ContactMina Raouf, MD
Outcome results
None listed