Healthy
Conditions
Keywords
oxytocin, emotional faces, attention, N2pc
Brief summary
To investigate whether intranasal oxytocin (24IU) treatment has a regulatory effect on attentional processing of emotional faces.
Detailed description
In a placebo-controlled double-blind between-subject design experiment, investigators plan to investigate the effect of oxytocin treatment on attentional processing of emotional faces. Subjects complete questionnaires in Chinese versions before treatment administration, including the Beck Depression Inventory, Autism Spectrum Quotient , Trait Anxiety Inventory, Toronto Alexithymia Scale, Multidimentional Assessment of Interoceptive Awareness. This experiment consists of two tasks including Emotional Face Cue-target Task and Visual Search Task. In the first task, subjects need to make a response to judge the position of target after a cue-target is presented. In the second task, subjects are asked to search the target U or inverted U placed on the nose of emotional/neutral faces and make an choices based on their oorientation. During these phases, subjects' response accuracy, response time and electrophysiological activity (ERP) are recorded.
Interventions
intranasal administration of oxytocin (24IU)
DRUGplacebo treatment
intranasal administration of placebo (24IU)
Sponsors
University of Electronic Science and Technology of China
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy subjects without past or current psychiatric or neurological disorders.
Exclusion criteria
* history of head injury * medical or psychiatric illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Response time in reponse to different emotional face targets. | 1 hour | Response time in discriminating which side (left or right) the emotional face target appear. |
| N2pc | 1 hour | N2pc is an enhanced negative event-related potential typically elicited at posterior electrodes (e.g., PO7 and PO8) contralateral to the target presented among distractors between 180 and 300 ms after the onset of stimuli. display. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Response accuracy in response to different emotional face targets. | 1 hour | Response accuracy is caculated by the precentage of correct responses among the total responses in discriminating the position (left or right side) of different face conditions. |
Countries
China
Outcome results
None listed