Klebsiella Pneumoniae Infection
Conditions
Brief summary
The objective of this study is to investigate the effect of the infection control measures based on the active screening of carbapenem-resistant Klebsiella pneumoniae and whole-genome based tracking and surveillance though the hospital.
Interventions
OTHERscreen of CRKP and infection control measure
For intervention group, we screen admitted patients for carbapenem-resistant Klebsiella pneumoniae and carry out 'Bundle' infection and control measures. When outbreak or tranmission of CRKP was observed, we take whole-genome sequencing to track origin and transmission route to decease CRKP rate.
Sponsors
Sumitomo Pharmaceuticals (Suzhou) Co. Ltd
Huashan Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. The patient was admitted to the ICU of neurosurgery in the west hospital of huashan hospital affiliated to fudan university from September 2019 to September 2021, or transferred from the ICU of another hospital 2. The patient is more than 18 years old and less than 80 years old, regardless of gender. 3. Informed consent of the patient;
Exclusion criteria
1. Patients participating in other clinical trials at the same time 2. Pregnant 4\. People who will affect the outcome of the study: whose specimens could not be received or not enough for testing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate the influence of WGS-based screen and control measures on the CRKP occurrence rate | 2 years |
Secondary
| Measure | Time frame |
|---|---|
| Analysis of transmission pattern and route pre and post WGS-based tracking | 2 years |
Countries
China
Outcome results
None listed