Bleeding, Covid-19, Thromboembolic Events
Conditions
Brief summary
The aims of the study are to to associate anticoagulation (AC) regime with outcome in critically ill patients with Covid-19. This will be done by describe baseline characteristics and comorbidities before hospital admission, level of organ support and dose of AC treatment and associate this with 28 days survival, survival outside ICU, thromboembolic event and bleeding complications.
Interventions
The patients will be categorised into three groups depending on initial regime of anticoagulants after arrival in the ICU.
Sponsors
Karolinska Institutet
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* laboratory confirmed positive test for SARS-CoV-2 * admitted to ICU because of critical illness due to covid-19
Exclusion criteria
* patients with treatment for thromboembolic complications at arrival to the ICU * short ICU length of stay defined as discharged the same or the following day as ICU admission
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 28-days ICU mortality | 28 days from ICU-admission | 28-days ICU mortality from admission to the ICU. Discontinue of ICU-care to palliative care counts as death. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of thromboembolic events | 28 days from ICU-admission | Thromboembolic events are defined as pulmonary emboli (PE), deep venous thrombus (DVT), ischemic stroke and other peripheral arterial emboli. PE is defined as PE verified by computer tomography or by findings of acute strain of the right heart on echocardiography combined with a clinical interpretation of the patients deteriorating as a probable PE stated in the medical records. DVT is defined as DVT verified with ultrasound. Ischemic stroke is defined as ischemic stroke verified by computer tomography. Peripheral arterial emboli are defined as peripheral arterial emboli verified by computer tomography. |
| Incidence of bleeding events | 28 days from ICU-admission | The event of bleeding will be defined by WHO modified bleeding scale as 1-4. |
| ICU-free days alive from ICU-admission. | 28 days from ICU-admission | ICU-free days alive during 28 days from ICU-admission. Counts as 0 days if discharged to ward for palliative treatment. |
Other
| Measure | Time frame | Description |
|---|---|---|
| D-dimer levels in the three groups groups | 28 days from ICU-admission | D-dimer every day it is measured during first 28 days from ICU-admission. |
Countries
Sweden
Outcome results
None listed