Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technque

Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technique: A Clinical Study With Cone Beam Computed Tomography Evaluation

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04410679

Enrollment

Registered

2020-06-01

Start date

2018-06-03

Completion date

2020-05-02

Last updated

2021-10-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Root Resorption

Keywords

Pulp revascularization, injectable Platelet rich fibrin, i-PRF, root resorption, CBCT

Brief summary

Currently Endodontics looks forward for regeneration rather than repair. Regenerative endodontic therapy was limited to pulp revascularization of necrotic pulp in immature teeth , followed by mature teeth. Recently pulp revascularization technique by induction of blood clot was applied in the treatment of inflammatory root resorption. So far, no clinical study for management of teeth with inflammatory internal root resorption by using injectable PRF revascularization has been described in the literature. Thus, this is the first clinical attempt to manage inflammatory root resorption in necrotic incisor teeth using injectable PRF regenerative approach.

Detailed description

13 teeth in a total of 10 patients with inflammatory root resorption will be treated using revascualrization technique, iPRF will be prepared and unjected in the canal after previous canal disinfection with calcium hydroxide for 2-4 weeks. cBCT will be taken preoperative and 12 month follow up period, also clinical and radiographic follow uo will be considered every 3 months for 1 year.

Interventions

BIOLOGICALinjectable PRF

blood sample and centrifuged to obtain i-PRF

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

13 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* patients 13-30 years old * no sex predilection * medically free * Suffering from internal inflammatory root resorption in permanent anterior mature teeth * associated with or without periapical radiolucency * no or grade I tooth mobility, and a pocket depth \<3 mm

Exclusion criteria

* old age * Medically medically compromised patients

Design outcomes

Primary

Measure	Time frame	Description
change in volumetric size of internal root resorption lesions	12 months	Measuring volumetric dimensions of resorption lesion pre and postoperatively using CBCT

Secondary

Measure	Time frame	Description
change in volumetric size of periapical lesions	12 months	Measuring volumetric dimensions of periapical lesion pre and postoperatively using CBCT

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026