Gynecologic Disease
Conditions
Brief summary
This study is performed to investigate the effect of opioid-free general anesthesia on the recovery quality after gynecological laparoscopy.
Detailed description
The quality of recovery after the surgery is assessed using the QoR 40. In addition, the various kinds of cytokine are assessed for the ancillary study.
Interventions
DRUGDexmedetomidine Hydrochloride
dexmedetomidine iv bolus followed by the infusion of 0.1-1 ug/kg/hr during general anesthesia
DRUGLidocaine Hydrochloride
lidocaine iv bolus followed by the infusion of 1.5 mg/kg/hr during general anesthesia
remifentanil iv infusion of 0.5-5 ng/ml (effect site concentration using TCI) during general anesthesia
Sponsors
The Catholic University of Korea
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patient scheduled for gynecological laparoscopic surgery
Exclusion criteria
1. refusal to participate in this study 2. emergent surgery 3. chronic pain requiring for pain killer 4. psychiatric disease 5. preoperative bradycardia or hypotension 6. allergy or history of the adverse effect to study drug 7. pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the quality of recovery | at 24 hour after the completion of surgery | The quality of recovery is assessed using questionnaire. This questionnaire includes 40 items. The score range is from 40 to 200. The higher score means the better quality of recovery after surgery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cytokine | during surgery | as ancillary study, to assess the various kinds of cytokines such as epinephrine, norepinephrine, interleukin-10, tumor necrosis factor-alpha. |
Countries
South Korea
Outcome results
None listed