Bulimia Nervosa
Conditions
Keywords
bulimia nervosa, binge eating, purging, fasting, eating disorder, control
Brief summary
This study examines the influence of acute fasting and eating on self-control in adult females with and without bulimia nervosa (BN). Specifically, the study team is investigating whether differences in behavior and brain activation in response to computer tasks after fasting and after eating a meal could help to explain the symptoms of bulimia nervosa. Data will be collected using questionnaires and a technology called magnetic resonance imaging (MRI).
Detailed description
Treatment-resistant binge eating and purging may be perpetuated by self-control deficits linked to reduced activation in frontostriatal circuits. To date, however, neurocognitive studies of BN have not assessed the dynamic computational processes underlying inhibition or considered the fact that individuals with BN oscillate between two extremes-under-controlled and over-controlled intake. The proposed study combines neuroimaging with computational modeling to investigate the influences of acute fasting and eating (i.e., metabolic states) on how the brains of women with bulimia nervosa (BN) adaptively prepare for and exert inhibitory control. More specifically, the study has the following main objectives: 1) To determine whether eating and fasting affect adaptive inhibitory control and related frontostriatal activation abnormally in BN; 2) To identify associations of BN severity with state-specific frontostriatal activation and behavior.
Interventions
OTHERfasting state
16 hours of fasting
OTHERfed state
fed a standardized meal
OTHERmagnetic resonance imaging
neuroimaging with computational modeling
Sponsors
Icahn School of Medicine at Mount Sinai
National Institute of Mental Health (NIMH)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)
Intervention model description
Two participant groups (one with and one without bulimia nervosa) will be scanned using MRI after they have fasted and after they have consumed a standardized meal. The order of these two scans will be counterbalanced across groups.
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Female * Aged 18 to 35 years * Currently between 85 and 130% of the expected weight for height * Right-handed * English-speaking Additional Inclusion Criteria for Women with Bulimia Nervosa: \- Meet DSM-5 criteria for bulimia nervosa
Exclusion criteria
* Medical instability * Ongoing medical treatment, medical condition, or psychiatric disorder that may interfere with study variables or participation * Shift work * Pregnancy, planned pregnancy, or lactation during the study period * Allergy to any of the ingredients in or unwillingness to consume the standardized meal or unwillingness to drink water during the fasting period * Any contraindication for fMRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Brain Activation Associated With P(Stop) | after 16 hours of fasting and at 30 minutes after a standardized meal (as least 24 hours apart, but not more than 7 days apart) | Frontostriatal activation modulated by the predicted need for inhibition (P(stop) (i.e., parametric modulation by p(Stop)), measured as the mean BOLD signal across voxels within the region of interest (ROI). Positive values indicate that neural activation increases as the predicted probability of needing to stop increases (i.e., stronger responses when stopping is predicted to be more likely), whereas negative values indicate that activation decreases as the predicted probability of needing to stop increases (i.e., greater activation when stopping is predicted to be less likely). |
| Brain Activation Associated With Prediction Errors (Unsigned) | after 16 hours of fasting and at 30 minutes after a standardized meal (as least 24 hours apart, but not more than 7 days apart) | Frontostriatal activation modulated by unsigned inhibitory control prediction errors (i.e., parametric modulation by absolute prediction error magnitude), measured as the mean BOLD signal across voxels within the region of interest (ROI). Positive values indicate that neural activation increases with the magnitude of unsigned prediction errors (i.e., stronger responses to more surprising outcomes), whereas negative values indicate that activation decreases as unsigned prediction errors increase (i.e., relative deactivation for more surprising outcomes). |
| Brain Activation Associated With Prediction Errors (Signed) | after 16 hours of fasting and at 30 minutes after a standardized meal (as least 24 hours apart, but not more than 7 days apart) | Frontostriatal activation modulated by signed inhibitory control prediction errors (i.e., parametric modulation by prediction error magnitude), measured as the mean BOLD signal across voxels within the region of interest (ROI). Positive values indicate that neural activation increases as signed prediction errors become more positive (i.e., stronger responses to the surprising need for control), whereas negative values indicate that activation decreases as signed prediction errors become more positive (i.e., stronger responses to the surprising lack of need for control). |
| Brain Activation Associated With Successful Inhibition | after 16 hours of fasting and at 30 minutes after a standardized meal (as least 24 hours apart, but not more than 7 days apart) | Frontostriatal activation associated with successful inhibition , measured as the mean BOLD signal across voxels within the region of interest (ROI) for the contrast of Successful Stop vs. Go trials. Positive values indicate activation associated with successful inhibition. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Stop Signal Reaction Time (SSRT) | after 16 hours of fasting and at 30 minutes after a standardized meal (as least 24 hours apart, but not more than 7 days apart) | Behavioral performance on the stop signal task, as measured by stop signal reaction time calculated as mean go reaction time minus the stop-signal delay at 50% successful inhibition (SSD₅₀). Higher SSRT means longer latency before failed inhibition. |
| Stop Signal Task Inhibition | after 16 hours of fasting and at 30 minutes after a standardized meal (as least 24 hours apart, but not more than 7 days apart) | Percent correct responses to stop trials on the Stop Signal Task measured by percent of stop trials on which participant successfully withheld a response (vs. failed to withhold response). |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORLaura A Berner, PhD
Department of Psychiatry, Icahn School of Medicine at Mount Sinai
Participant flow
Recruitment details
100 individuals were recruited (from New York City and the surrounding community and the Center of Excellence in Eating and Weight Disorders at Mount Sinai) and signed informed consent for the full study.
Pre-assignment details
Subjects completed several screening processes to determine eligibility.
Participants by arm
| Arm | Count |
|---|---|
| Participants With Bulimia Nervosa Participants were scanned after 16 hours of fasting (Fasted Scan) on one day, and were scanned after a standardized meal on a separate day (Fed Scan). The order of these fasted and fed visits was counterbalanced across participants. | 32 |
| Healthy Control Participants Without Bulimia Nervosa Participants were scanned after 16 hours of fasting (Fasted Scan) on one day, and were scanned after a standardized meal on a separate day (Fed Scan). The order of these fasted and fed visits was counterbalanced across participants. | 32 |
| Total | 64 |
Baseline characteristics
| Characteristic | Participants With Bulimia Nervosa | Healthy Control Participants Without Bulimia Nervosa | Total |
|---|---|---|---|
| Age, Continuous | 25.00 years STANDARD_DEVIATION 4.64 | 24.88 years STANDARD_DEVIATION 3.65 | 24.94 years STANDARD_DEVIATION 4.14 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 26 Participants | 25 Participants | 51 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 6 Participants | 7 Participants | 13 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants | 0 Participants | 0 Participants |
| Number of fasting episodes Healthy Control | — | 0 number of episodes in the past 28 days STANDARD_DEVIATION 0 | 0 number of episodes in the past 28 days STANDARD_DEVIATION 0 |
| Number of fasting episodes Participants with Bulimia Nervosa | 8.69 number of episodes in the past 28 days STANDARD_DEVIATION 7.75 | — | 8.69 number of episodes in the past 28 days STANDARD_DEVIATION 7.75 |
| Number of objective binge eating episodes Healthy Control | — | 0 episodes in past 28 days STANDARD_DEVIATION 0 | 0 episodes in past 28 days STANDARD_DEVIATION 0 |
| Number of objective binge eating episodes Participants with Bulimia Nervosa | 12.7 episodes in past 28 days STANDARD_DEVIATION 11.4 | — | 12.7 episodes in past 28 days STANDARD_DEVIATION 11.4 |
| Number of self-induced vomiting episodes Healthy Control | — | 0 number of episodes in the past 28 days STANDARD_DEVIATION 0 | 0 number of episodes in the past 28 days STANDARD_DEVIATION 0 |
| Number of self-induced vomiting episodes Participants with Bulimia Nervosa | 10.2 number of episodes in the past 28 days STANDARD_DEVIATION 13.1 | — | 10.2 number of episodes in the past 28 days STANDARD_DEVIATION 13.1 |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Asian | 11 Participants | 12 Participants | 23 Participants |
| Race (NIH/OMB) Black or African American | 2 Participants | 6 Participants | 8 Participants |
| Race (NIH/OMB) More than one race | 1 Participants | 1 Participants | 2 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 4 Participants | 3 Participants | 7 Participants |
| Race (NIH/OMB) White | 14 Participants | 10 Participants | 24 Participants |
| Sex: Female, Male Female | 32 Participants | 32 Participants | 64 Participants |
| Sex: Female, Male Male | 0 Participants | 0 Participants | 0 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 32 | 0 / 32 |
| other Total, other adverse events | 1 / 32 | 4 / 32 |
| serious Total, serious adverse events | 0 / 32 | 0 / 32 |
Outcome results
Primary
Brain Activation Associated With Prediction Errors (Signed)
Frontostriatal activation modulated by signed inhibitory control prediction errors (i.e., parametric modulation by prediction error magnitude), measured as the mean BOLD signal across voxels within the region of interest (ROI). Positive values indicate that neural activation increases as signed prediction errors become more positive (i.e., stronger responses to the surprising need for control), whereas negative values indicate that activation decreases as signed prediction errors become more positive (i.e., stronger responses to the surprising lack of need for control).
Time frame: after 16 hours of fasting and at 30 minutes after a standardized meal (as least 24 hours apart, but not more than 7 days apart)
Population: Brain imaging data were pre-processed and analyzed for each group and state. Data from 8 participants were excluded: 2 HC due to technical malfunction that caused loss of behavioral data from their 2nd MRI visit, 1 HC for incidental finding on MRI (not identified until after their 2nd scan), 2 (1 BN, 1 HC) for insufficient trials for analysis in a key condition at one or both scans, and 3 BN for excessive movement (\>20% of TRs with ≥0.5mm framewise displacement) at one or both scans.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left DLPFC Brain Activation | 0.05 BOLD Signal | Standard Deviation 0.29 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left Caudate Brain Activation | 0.16 BOLD Signal | Standard Deviation 0.35 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left Putamen Brain Activation | -0.04 BOLD Signal | Standard Deviation 0.25 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left Dorsal ACC Activation | 0.03 BOLD Signal | Standard Deviation 0.36 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left VLPFC Brain Activation | 0.02 BOLD Signal | Standard Deviation 0.33 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right DLPFC Brain Activation | 0.25 BOLD Signal | Standard Deviation 0.33 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right Caudate Brain Activation | 0.15 BOLD Signal | Standard Deviation 0.37 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right Putamen Brain Activation | 0.12 BOLD Signal | Standard Deviation 0.29 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right Dorsal ACC Activation | 0.09 BOLD Signal | Standard Deviation 0.31 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right VLPFC Brain Activation | 0.28 BOLD Signal | Standard Deviation 0.27 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left Putamen Brain Activation | -0.07 BOLD Signal | Standard Deviation 0.33 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right Dorsal ACC Activation | 0.11 BOLD Signal | Standard Deviation 0.32 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left Dorsal ACC Activation | 0.09 BOLD Signal | Standard Deviation 0.36 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left VLPFC Brain Activation | 0.10 BOLD Signal | Standard Deviation 0.41 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right DLPFC Brain Activation | 0.24 BOLD Signal | Standard Deviation 0.36 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right Caudate Brain Activation | 0.09 BOLD Signal | Standard Deviation 0.36 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right VLPFC Brain Activation | 0.29 BOLD Signal | Standard Deviation 0.27 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right Putamen Brain Activation | 0.06 BOLD Signal | Standard Deviation 0.28 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left DLPFC Brain Activation | 0.07 BOLD Signal | Standard Deviation 0.4 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left Caudate Brain Activation | 0.16 BOLD Signal | Standard Deviation 0.34 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right Putamen Brain Activation | 0.06 BOLD Signal | Standard Deviation 0.33 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right Caudate Brain Activation | 0.04 BOLD Signal | Standard Deviation 0.48 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right VLPFC Brain Activation | 0.44 BOLD Signal | Standard Deviation 0.31 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left DLPFC Brain Activation | 0.03 BOLD Signal | Standard Deviation 0.4 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left Dorsal ACC Activation | 0.10 BOLD Signal | Standard Deviation 0.43 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right DLPFC Brain Activation | 0.28 BOLD Signal | Standard Deviation 0.39 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right Dorsal ACC Activation | 0.11 BOLD Signal | Standard Deviation 0.36 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left Caudate Brain Activation | 0.06 BOLD Signal | Standard Deviation 0.45 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left VLPFC Brain Activation | 0.07 BOLD Signal | Standard Deviation 0.39 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left Putamen Brain Activation | -0.07 BOLD Signal | Standard Deviation 0.34 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left VLPFC Brain Activation | 0.03 BOLD Signal | Standard Deviation 0.26 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right Putamen Brain Activation | 0.02 BOLD Signal | Standard Deviation 0.4 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right DLPFC Brain Activation | 0.30 BOLD Signal | Standard Deviation 0.38 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right VLPFC Brain Activation | 0.36 BOLD Signal | Standard Deviation 0.32 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right Caudate Brain Activation | 0.10 BOLD Signal | Standard Deviation 0.4 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left Caudate Brain Activation | 0.05 BOLD Signal | Standard Deviation 0.41 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left Putamen Brain Activation | -0.13 BOLD Signal | Standard Deviation 0.41 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left Dorsal ACC Activation | -0.01 BOLD Signal | Standard Deviation 0.31 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Left DLPFC Brain Activation | 0.02 BOLD Signal | Standard Deviation 0.32 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Signed) | Right Dorsal ACC Activation | 0.02 BOLD Signal | Standard Deviation 0.28 |
Primary
Brain Activation Associated With Prediction Errors (Unsigned)
Frontostriatal activation modulated by unsigned inhibitory control prediction errors (i.e., parametric modulation by absolute prediction error magnitude), measured as the mean BOLD signal across voxels within the region of interest (ROI). Positive values indicate that neural activation increases with the magnitude of unsigned prediction errors (i.e., stronger responses to more surprising outcomes), whereas negative values indicate that activation decreases as unsigned prediction errors increase (i.e., relative deactivation for more surprising outcomes).
Time frame: after 16 hours of fasting and at 30 minutes after a standardized meal (as least 24 hours apart, but not more than 7 days apart)
Population: Brain imaging data were pre-processed and analyzed for each group and state. Data from 8 participants were excluded: 2 HC due to technical malfunction that caused loss of behavioral data from their 2nd MRI visit, 1 HC for incidental finding on MRI (not identified until after their 2nd scan), 2 (1 BN, 1 HC) for insufficient trials for analysis in a key condition at one or both scans, and 3 BN for excessive movement (\>20% of TRs with ≥0.5mm framewise displacement) at one or both scans.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left DLPFC Brain Activation | 0.09 BOLD Signal | Standard Deviation 0.29 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left Caudate Brain Activation | 0.07 BOLD Signal | Standard Deviation 0.35 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left Putamen Brain Activation | -0.03 BOLD Signal | Standard Deviation 0.26 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left Dorsal ACC Activation | -0.02 BOLD Signal | Standard Deviation 0.32 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left VLPFC Brain Activation | 0.04 BOLD Signal | Standard Deviation 0.31 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right DLPFC Brain Activation | 0.33 BOLD Signal | Standard Deviation 0.37 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right Caudate Brain Activation | 0.12 BOLD Signal | Standard Deviation 0.38 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right Putamen Brain Activation | 0.13 BOLD Signal | Standard Deviation 0.31 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right Dorsal ACC Activation | 0.05 BOLD Signal | Standard Deviation 0.28 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right VLPFC Brain Activation | 0.29 BOLD Signal | Standard Deviation 0.26 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left Putamen Brain Activation | -0.02 BOLD Signal | Standard Deviation 0.32 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right Dorsal ACC Activation | 0.10 BOLD Signal | Standard Deviation 0.25 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left Dorsal ACC Activation | 0.07 BOLD Signal | Standard Deviation 0.29 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left VLPFC Brain Activation | 0.11 BOLD Signal | Standard Deviation 0.36 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right DLPFC Brain Activation | 0.32 BOLD Signal | Standard Deviation 0.31 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right Caudate Brain Activation | 0.12 BOLD Signal | Standard Deviation 0.29 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right VLPFC Brain Activation | 0.28 BOLD Signal | Standard Deviation 0.23 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right Putamen Brain Activation | 0.08 BOLD Signal | Standard Deviation 0.28 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left DLPFC Brain Activation | 0.13 BOLD Signal | Standard Deviation 0.35 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left Caudate Brain Activation | 0.11 BOLD Signal | Standard Deviation 0.3 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right Putamen Brain Activation | 0.14 BOLD Signal | Standard Deviation 0.35 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right Caudate Brain Activation | 0.07 BOLD Signal | Standard Deviation 0.53 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right VLPFC Brain Activation | 0.45 BOLD Signal | Standard Deviation 0.3 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left DLPFC Brain Activation | 0.08 BOLD Signal | Standard Deviation 0.4 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left Dorsal ACC Activation | 0.09 BOLD Signal | Standard Deviation 0.41 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right DLPFC Brain Activation | 0.38 BOLD Signal | Standard Deviation 0.38 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right Dorsal ACC Activation | 0.09 BOLD Signal | Standard Deviation 0.35 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left Caudate Brain Activation | 0.06 BOLD Signal | Standard Deviation 0.46 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left VLPFC Brain Activation | 0.09 BOLD Signal | Standard Deviation 0.4 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left Putamen Brain Activation | 0.01 BOLD Signal | Standard Deviation 0.35 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left VLPFC Brain Activation | 0.04 BOLD Signal | Standard Deviation 0.26 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right Putamen Brain Activation | 0.07 BOLD Signal | Standard Deviation 0.35 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right DLPFC Brain Activation | 0.39 BOLD Signal | Standard Deviation 0.36 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right VLPFC Brain Activation | 0.34 BOLD Signal | Standard Deviation 0.3 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right Caudate Brain Activation | 0.14 BOLD Signal | Standard Deviation 0.32 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left Caudate Brain Activation | 0.08 BOLD Signal | Standard Deviation 0.32 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left Putamen Brain Activation | -0.06 BOLD Signal | Standard Deviation 0.39 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left Dorsal ACC Activation | -0.01 BOLD Signal | Standard Deviation 0.26 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Left DLPFC Brain Activation | 0.09 BOLD Signal | Standard Deviation 0.29 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Prediction Errors (Unsigned) | Right Dorsal ACC Activation | 0.01 BOLD Signal | Standard Deviation 0.24 |
Primary
Brain Activation Associated With P(Stop)
Frontostriatal activation modulated by the predicted need for inhibition (P(stop) (i.e., parametric modulation by p(Stop)), measured as the mean BOLD signal across voxels within the region of interest (ROI). Positive values indicate that neural activation increases as the predicted probability of needing to stop increases (i.e., stronger responses when stopping is predicted to be more likely), whereas negative values indicate that activation decreases as the predicted probability of needing to stop increases (i.e., greater activation when stopping is predicted to be less likely).
Time frame: after 16 hours of fasting and at 30 minutes after a standardized meal (as least 24 hours apart, but not more than 7 days apart)
Population: Brain imaging data were pre-processed and analyzed for each group and state. Data from 8 participants were excluded: 2 HC due to technical malfunction that caused loss of behavioral data from their 2nd MRI visit, 1 HC for incidental finding on MRI (not identified until after their 2nd scan), 2 (1 BN, 1 HC) for insufficient trials for analysis in a key condition at one or both scans, and 3 BN for excessive movement (\>20% of TRs with ≥0.5mm framewise displacement) at one or both scans.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With P(Stop) | Left DLPFC Brain Activation | 0.02 BOLD Signal | Standard Deviation 0.32 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With P(Stop) | Left Caudate Brain Activation | -0.16 BOLD Signal | Standard Deviation 0.36 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With P(Stop) | Left Putamen Brain Activation | -0.06 BOLD Signal | Standard Deviation 0.28 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With P(Stop) | Left Dorsal ACC Activation | -0.07 BOLD Signal | Standard Deviation 0.27 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With P(Stop) | Left VLPFC Brain Activation | 0.01 BOLD Signal | Standard Deviation 0.28 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With P(Stop) | Right DLPFC Brain Activation | 0.07 BOLD Signal | Standard Deviation 0.36 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With P(Stop) | Right Caudate Brain Activation | -0.12 BOLD Signal | Standard Deviation 0.42 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With P(Stop) | Right Putamen Brain Activation | -0.05 BOLD Signal | Standard Deviation 0.31 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With P(Stop) | Right Dorsal ACC Activation | -0.07 BOLD Signal | Standard Deviation 0.25 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With P(Stop) | Right VLPFC Brain Activation | 0.01 BOLD Signal | Standard Deviation 0.33 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With P(Stop) | Left Putamen Brain Activation | -0.01 BOLD Signal | Standard Deviation 0.27 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With P(Stop) | Right Dorsal ACC Activation | 0 BOLD Signal | Standard Deviation 0.23 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With P(Stop) | Left Dorsal ACC Activation | 0 BOLD Signal | Standard Deviation 0.29 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With P(Stop) | Left VLPFC Brain Activation | 0.03 BOLD Signal | Standard Deviation 0.29 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With P(Stop) | Right DLPFC Brain Activation | 0.14 BOLD Signal | Standard Deviation 0.37 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With P(Stop) | Right Caudate Brain Activation | 0 BOLD Signal | Standard Deviation 0.38 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With P(Stop) | Right VLPFC Brain Activation | 0.02 BOLD Signal | Standard Deviation 0.24 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With P(Stop) | Right Putamen Brain Activation | -0.01 BOLD Signal | Standard Deviation 0.29 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With P(Stop) | Left DLPFC Brain Activation | 0.11 BOLD Signal | Standard Deviation 0.35 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With P(Stop) | Left Caudate Brain Activation | -0.06 BOLD Signal | Standard Deviation 0.35 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With P(Stop) | Right Putamen Brain Activation | 0.02 BOLD Signal | Standard Deviation 0.35 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With P(Stop) | Right Caudate Brain Activation | -0.02 BOLD Signal | Standard Deviation 0.32 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With P(Stop) | Right VLPFC Brain Activation | 0.03 BOLD Signal | Standard Deviation 0.29 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With P(Stop) | Left DLPFC Brain Activation | 0.04 BOLD Signal | Standard Deviation 0.41 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With P(Stop) | Left Dorsal ACC Activation | -0.08 BOLD Signal | Standard Deviation 0.3 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With P(Stop) | Right DLPFC Brain Activation | 0.14 BOLD Signal | Standard Deviation 0.36 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With P(Stop) | Right Dorsal ACC Activation | -0.05 BOLD Signal | Standard Deviation 0.26 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With P(Stop) | Left Caudate Brain Activation | -0.05 BOLD Signal | Standard Deviation 0.31 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With P(Stop) | Left VLPFC Brain Activation | -0.01 BOLD Signal | Standard Deviation 0.32 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With P(Stop) | Left Putamen Brain Activation | 0.02 BOLD Signal | Standard Deviation 0.31 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With P(Stop) | Left VLPFC Brain Activation | 0.02 BOLD Signal | Standard Deviation 0.28 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With P(Stop) | Right Putamen Brain Activation | -0.01 BOLD Signal | Standard Deviation 0.3 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With P(Stop) | Right DLPFC Brain Activation | 0.12 BOLD Signal | Standard Deviation 0.34 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With P(Stop) | Right VLPFC Brain Activation | -0.01 BOLD Signal | Standard Deviation 0.27 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With P(Stop) | Right Caudate Brain Activation | -0.01 BOLD Signal | Standard Deviation 0.45 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With P(Stop) | Left Caudate Brain Activation | -0.07 BOLD Signal | Standard Deviation 0.39 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With P(Stop) | Left Putamen Brain Activation | -0.01 BOLD Signal | Standard Deviation 0.29 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With P(Stop) | Left Dorsal ACC Activation | -0.06 BOLD Signal | Standard Deviation 0.31 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With P(Stop) | Left DLPFC Brain Activation | 0.05 BOLD Signal | Standard Deviation 0.34 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With P(Stop) | Right Dorsal ACC Activation | -0.04 BOLD Signal | Standard Deviation 0.29 |
Primary
Brain Activation Associated With Successful Inhibition
Frontostriatal activation associated with successful inhibition , measured as the mean BOLD signal across voxels within the region of interest (ROI) for the contrast of Successful Stop vs. Go trials. Positive values indicate activation associated with successful inhibition.
Time frame: after 16 hours of fasting and at 30 minutes after a standardized meal (as least 24 hours apart, but not more than 7 days apart)
Population: Brain imaging data were pre-processed and analyzed for each group and state. Data from 8 participants were excluded: 2 HC due to technical malfunction that caused loss of behavioral data from their 2nd MRI visit, 1 HC for incidental finding on MRI (not identified until after their 2nd scan), 2 (1 BN, 1 HC) for insufficient trials for analysis in a key condition at one or both scans, and 3 BN for excessive movement (\>20% of TRs with ≥0.5mm framewise displacement) at one or both scans.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Right Caudate Brain Activation | 0.22 BOLD Signal | Standard Deviation 0.34 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Left Caudate Brain Activation | 0.18 BOLD Signal | Standard Deviation 0.3 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Left VLPFC Brain Activation | 0.02 BOLD Signal | Standard Deviation 0.32 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Left Dorsal ACC Activation | -0.04 BOLD Signal | Standard Deviation 0.32 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Right Dorsal ACC Activation | 0.03 BOLD Signal | Standard Deviation 0.27 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Left DLPFC Brain Activation | 0.06 BOLD Signal | Standard Deviation 0.27 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Right VLPFC Brain Activation | 0.31 BOLD Signal | Standard Deviation 0.25 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Right Putamen Brain Activation | 0.18 BOLD Signal | Standard Deviation 0.28 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Right DLPFC Brain Activation | 0.29 BOLD Signal | Standard Deviation 0.32 |
| Participants With Bulimia Nervosa (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Left Putamen Brain Activation | 0.06 BOLD Signal | Standard Deviation 0.23 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Successful Inhibition | Right Putamen Brain Activation | 0.16 BOLD Signal | Standard Deviation 0.3 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Successful Inhibition | Right Dorsal ACC Activation | 0.13 BOLD Signal | Standard Deviation 0.32 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Successful Inhibition | Left DLPFC Brain Activation | 0.11 BOLD Signal | Standard Deviation 0.4 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Successful Inhibition | Right VLPFC Brain Activation | 0.34 BOLD Signal | Standard Deviation 0.28 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Successful Inhibition | Left Putamen Brain Activation | 0.09 BOLD Signal | Standard Deviation 0.33 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Successful Inhibition | Left Dorsal ACC Activation | 0.09 BOLD Signal | Standard Deviation 0.37 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Successful Inhibition | Left VLPFC Brain Activation | 0.12 BOLD Signal | Standard Deviation 0.44 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Successful Inhibition | Right DLPFC Brain Activation | 0.32 BOLD Signal | Standard Deviation 0.38 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Successful Inhibition | Left Caudate Brain Activation | 0.21 BOLD Signal | Standard Deviation 0.31 |
| Participants With Bulimia Nervosa (Fed Scan) | Brain Activation Associated With Successful Inhibition | Right Caudate Brain Activation | 0.16 BOLD Signal | Standard Deviation 0.32 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Left Putamen Brain Activation | 0.07 BOLD Signal | Standard Deviation 0.37 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Right VLPFC Brain Activation | 0.51 BOLD Signal | Standard Deviation 0.3 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Right Caudate Brain Activation | 0.15 BOLD Signal | Standard Deviation 0.52 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Right DLPFC Brain Activation | 0.43 BOLD Signal | Standard Deviation 0.37 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Left Caudate Brain Activation | 0.12 BOLD Signal | Standard Deviation 0.48 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Right Dorsal ACC Activation | 0.09 BOLD Signal | Standard Deviation 0.36 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Left Dorsal ACC Activation | 0.06 BOLD Signal | Standard Deviation 0.43 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Left DLPFC Brain Activation | 0.08 BOLD Signal | Standard Deviation 0.36 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Right Putamen Brain Activation | 0.18 BOLD Signal | Standard Deviation 0.36 |
| Healthy Control Participants (Fasted Scan) | Brain Activation Associated With Successful Inhibition | Left VLPFC Brain Activation | 0.07 BOLD Signal | Standard Deviation 0.38 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Successful Inhibition | Right VLPFC Brain Activation | 0.40 BOLD Signal | Standard Deviation 0.3 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Successful Inhibition | Left DLPFC Brain Activation | 0.06 BOLD Signal | Standard Deviation 0.33 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Successful Inhibition | Left Caudate Brain Activation | 0.10 BOLD Signal | Standard Deviation 0.36 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Successful Inhibition | Left Putamen Brain Activation | 0.04 BOLD Signal | Standard Deviation 0.39 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Successful Inhibition | Left Dorsal ACC Activation | -0.04 BOLD Signal | Standard Deviation 0.28 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Successful Inhibition | Left VLPFC Brain Activation | 0.02 BOLD Signal | Standard Deviation 0.23 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Successful Inhibition | Right DLPFC Brain Activation | 0.39 BOLD Signal | Standard Deviation 0.38 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Successful Inhibition | Right Caudate Brain Activation | 0.19 BOLD Signal | Standard Deviation 0.34 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Successful Inhibition | Right Dorsal ACC Activation | 0 BOLD Signal | Standard Deviation 0.25 |
| Healthy Control Participants (Fed Scan) | Brain Activation Associated With Successful Inhibition | Right Putamen Brain Activation | 0.15 BOLD Signal | Standard Deviation 0.39 |
Secondary
Stop Signal Reaction Time (SSRT)
Behavioral performance on the stop signal task, as measured by stop signal reaction time calculated as mean go reaction time minus the stop-signal delay at 50% successful inhibition (SSD₅₀). Higher SSRT means longer latency before failed inhibition.
Time frame: after 16 hours of fasting and at 30 minutes after a standardized meal (as least 24 hours apart, but not more than 7 days apart)
Population: Brain imaging data were pre-processed and analyzed for each group and state. Data from 8 participants were excluded: 2 HC due to technical malfunction that caused loss of behavioral data from their 2nd MRI visit, 1 HC for incidental finding on MRI (not identified until after their 2nd scan), 2 (1 BN, 1 HC) for insufficient trials for analysis in a key condition at one or both scans, and 3 BN for excessive movement (\>20% of TRs with ≥0.5mm framewise displacement) at one or both scans.
| Arm | Measure | Group | Value (MEDIAN) | Dispersion |
|---|---|---|---|---|
| Participants With Bulimia Nervosa (Fasted Scan) | Stop Signal Reaction Time (SSRT) | Fasted Scan | 164.37 Milliseconds | Standard Error 16.31 |
| Participants With Bulimia Nervosa (Fasted Scan) | Stop Signal Reaction Time (SSRT) | Fed Scan | 170.80 Milliseconds | Standard Error 79.14 |
| Participants With Bulimia Nervosa (Fed Scan) | Stop Signal Reaction Time (SSRT) | Fasted Scan | 151.70 Milliseconds | Standard Error 18.89 |
| Participants With Bulimia Nervosa (Fed Scan) | Stop Signal Reaction Time (SSRT) | Fed Scan | 166.58 Milliseconds | Standard Error 13.99 |
Secondary
Stop Signal Task Inhibition
Percent correct responses to stop trials on the Stop Signal Task measured by percent of stop trials on which participant successfully withheld a response (vs. failed to withhold response).
Time frame: after 16 hours of fasting and at 30 minutes after a standardized meal (as least 24 hours apart, but not more than 7 days apart)
Population: Brain imaging data were pre-processed and analyzed for each group and state. Data from 8 participants were excluded: 2 HC due to technical malfunction that caused loss of behavioral data from their 2nd MRI visit, 1 HC for incidental finding on MRI (not identified until after their 2nd scan), 2 (1 BN, 1 HC) for insufficient trials for analysis in a key condition at one or both scans, and 3 BN for excessive movement (\>20% of TRs with ≥0.5mm framewise displacement) at one or both scans.
| Arm | Measure | Group | Value (MEDIAN) | Dispersion |
|---|---|---|---|---|
| Participants With Bulimia Nervosa (Fasted Scan) | Stop Signal Task Inhibition | Fasted Scan | 57.29 percent correct responses | Standard Error 2 |
| Participants With Bulimia Nervosa (Fasted Scan) | Stop Signal Task Inhibition | Fed Scan | 53.12 percent correct responses | Standard Error 3.05 |
| Participants With Bulimia Nervosa (Fed Scan) | Stop Signal Task Inhibition | Fasted Scan | 55.56 percent correct responses | Standard Error 2.62 |
| Participants With Bulimia Nervosa (Fed Scan) | Stop Signal Task Inhibition | Fed Scan | 56.25 percent correct responses | Standard Error 2.93 |