Prosthetic Joint Infection, Staphylococcal Infections
Conditions
Keywords
Staphylococcus lugdunensis, Prosthetic Joint Infection, biofilm
Brief summary
Staphylococcus lugdunensis is a coagulase-negative staphylococcus belonging to the human commensal cutaneous flora, and has been little studied in the field of prosthetic joint infections. However, it shares many virulence traits with Staphylococcus aureus, including many adhesins and its ability to form biofilm, and the few series of cases reports a significant failure rate.
Interventions
OTHERProthestic joint infection due to Staphylococcus lugdunensis
description of prosthetic joint infection with Staphylococcus lugdunensis
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* infection of joint prosthesis (whatever its type) with Staphylococcus lugdunensis defined by the positivity of at least 2 gold-standard samples (joint puncture, intraoperative samples) with S. lugdunensis; OR * a single positive gold-standard sample or positive blood cultures AND formal clinical, radiological, biological and / or pathological arguments in favor of an infection of joint prosthesis AND absence of other pathogenic agent
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of PJI infection with Staphylococcus lugdunensis | between 2010 and 2020 | proportion of patients having PJI infection with Staphylococcus lugdunensis, alone or with other bacteria |
| Description of PJI infection with Staphylococcus lugdunensis : type | Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption | type of PJI : knee or hip prosthesis |
| Description of PJI infection with Staphylococcus lugdunensis : evolution | Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption | evolution of PJI :evolution between prosthesis placement and the onset of symptoms, gateway to infection |
| Description of patients with PJI infection due to Staphylococcus lugdunensis | Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption | type of patients: age, CMI |
| Description of patients with PJI infection due to Staphylococcus lugdunensis : follow up | Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption | duration of the follow up of patients |
| Description of patients with PJI infection due to Staphylococcus lugdunensis : medical treatment | Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption | description and duration of antibiotics |
| Description of patients with PJI infection due to Staphylococcus lugdunensis : surgical treatment | Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption | description of surgery performed : DAIR, one-step exchange, two-step exchange |
| rate of treatment failure | Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption | Treatment failure is defined by local clinical and/or microbiological relapse; and/or need for additional surgery; death of septic origin |
Countries
France
Outcome results
None listed