Acute Leukemia, Cardiac Toxicity, Childhood Cancer
Conditions
Brief summary
Compelling epidemiological evidence indicates that alterations of relative telomere length (RTL) are associated with cardiac dysfunction caused by chemotherapy in children with acute leukemia (AL).The aim of this study was to explore association between RTL content in peripheral blood cells could be used as a risk predictor for severity of cardiac damage.
Interventions
DIAGNOSTIC_TESTRelative telomere length
Relative telomere length in peripheral blood cell
Sponsors
Air Force Military Medical University, China
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 16 Years
Healthy volunteers
Yes
Inclusion criteria
* 1\. histological confirmed acute leukemia; 2. Preparing for chemotherapy;
Exclusion criteria
* 1.history of other malignancy; 2.blood transfusion within one month or prior bone marrow transplantation; 3.patients who reluctant to sign informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relative telomere length | From date of admission until the date of discharging from hospital, assessed up to 5 days | The ratio of RTL to hemoglobin contents was calculated for each sample from standard curves. After that, the ratio for each sample was normalized to a calibrator DNA in order to standardize between different runs, and then defined as the measurement of relative mtDNA contents.Relative expression of mtDNA were measured in young adults suffered from AL. |
Countries
China
Outcome results
None listed