LUNG FIBROTIC CHANGES ASSOCIATED WITH SARS-CoV-2 INFECTION

Conditions

Pulmonary Fibrosis

Brief summary

Prospective, observational, multicenter study that will evaluate the changes in lung function that patients admitted with SARS-CoV-2 pneumonia will present according to the level of severity at 4, 12, 26 and 52 weeks after hospital discharge.

Detailed description

The project consists of a prospective, observational, multicenter study that will evaluate changes in lung function (forced spirometry, measurement of static lung volumes using plethysmography and pulmonary carbon monoxide diffusion test) that patients admitted with pneumonia will present. caused by SARS-CoV-2 according to the level of severity at 4, 12, 26 and 52 weeks after discharge from hospital. Restrictive pulmonary abnormalities will be confirmed by imaging tests (high resolution chest CT).

González-Villaescusa C, Tarrasó Castillo J, Martínez-Pitarch D, Riesco Miranda JA, García-Castillo E, Gotera Rivera C, Carrasco Hernández L, Sobradillo Ecenarro P, Signes-Costa J, Naval Sendra E, Callejas González FJ, Yordi León A, Vigil Gimenez L, Núñez Fernández M, Palop Cervera M, Carbonell-Asins JA, Agusti A, Field Investigators.

2025-11-17

10.1016/j.opresp.2025.100519

Evolution and description of long term COVID pulmonary sequelae: Study design (Preprint)

Julia Tarrasó, Juan Antonio Carbonell‐Asins, Estrella Fernández‐Fabrellas, Belén Safont, José N. Sancho-Chust et al. (14 authors)

2025-10-22

10.2196/preprints.86306

Metabolomic Biomarkers of Pulmonary Fibrosis in COVID‐19 Patients One Year After Hospital Discharge

Marina Botello‐Marabotto, Julia Tarrasó, Alba Mulet, Lucía Presa‐Fernández, Estrella Fernández‐Fabrellas et al. (12 authors)

Journal of Medical Virology2025-03-011 citations

10.1002/jmv.70289

Lung function and radiological findings 1 year after COVID-19: a prospective follow-up

Julia Tarrasó, Belén Safont, Juan Antonio Carbonell‐Asins, Estrella Fernández‐Fabrellas, José N. Sancho-Chust et al. (37 authors)

Respiratory Research2022-09-1280 citations

10.1186/s12931-022-02166-8

Lung Function, Radiological Findings and Biomarkers of Fibrogenesis in a Cohort of COVID-19 Patients Six Months After Hospital Discharge.

Safont B, Tarraso J, Rodriguez-Borja E, Fernández-Fabrellas E, Sancho-Chust JN, Molina V, Lopez-Ramirez C, Lope-Martinez A, Cabanes L, Andreu AL, Herrera S, Lahosa C, Ros JA, Rodriguez-Hermosa JL, Soriano JB, Moret-Tatay I, Carbonell-Asins JA, Mulet A, Signes-Costa J.

2021-09-0358 citations

10.1016/j.arbres.2021.08.014

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

No

Inclusion criteria

* Patients admitted for bilateral pneumonia caused by SARS-CoV-2 (confirmed by PCR). * Age over 18 years. * Acceptance of informed consent. * Life expectancy over 1 year.

Exclusion criteria

* Patients with a previous diagnosis of interstitial lung disease. * Inability to attend review visits.

Design outcomes

Primary

Measure	Time frame	Description
Pulmonary fibrotic changes, short and medium term	12 months	To analyze the number of patients who will develop pulmonary fibrotic changes, in the short and medium term, after surviving a bilateral pulmonary infection by SARS-CoV-2
Degree of lung function impairment	6 and 12 months	To study the degree of lung function impairment, specifically the restrictive changes in functional capacity and diffusion alterations and its relationship with clinical variables.
Biological markers	1 month	Examine the biological markers in the patients who will present this dysregulation of the curative response that will give rise to pulmonary fibrosing phenomena.

Countries

Spain

Outcome results