Anesthesia on Optic Nerve Sheath Diameter

The Effect Of Minimal and High Flow Anesthesia on Optic Nerve Sheath Diameter in Laparotomic Gynecological Surgery

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04407715

Enrollment

Registered

2020-05-29

Start date

2019-04-30

Completion date

2019-12-30

Last updated

2026-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Optic Nerve Sheath Diameter

Keywords

Minimal Flow Anesthesia, Optic Nerve Sheath Diameter

Brief summary

Different amounts of anesthetic gas can be used in the obstetric gynecological surgery operations to be performed with open method. Researchers aimed to compare the effect of gas changes on intraocular nerve diameter by ultrasonography.

Detailed description

A total of 80 patients who underwent laparotomic gynecological surgery were divided into two groups prospectively: high flow of 2 L/min and minimal flow of 0.5 L/min. Anesthesia was maintained with 50% oxygen-50% air at 2 L/min and desflurane at 1.1 MAC in Group 1 (n=40) and with 50% oxygen-50% air at 2 L/min and desflurane at 1.1 MAC in Group 2 (n=40). After 10-15 minutes, group 2 was administered minimal flow with 50-60% oxygen-40-50% air at 0.5 L/min and desflurane, and 10 minutes before the end of the surgery, the patients were switched to high flow with 50% oxygen-50% air at 2 L/min.

Interventions

PROCEDUREThe Effect Of Minimal and High Flow Anesthesia on Optic Nerve Sheath Diamater

The patients were randomly allocated to one of the two groups of fresh gas flows using the closed-envelope technique: 2 L/min high flow and 0.5 L/min minimal flow.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Intervention model description

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Aged 18-65 years * ASA I-II * Who underwent laparotomic gynecological surgery

Exclusion criteria

* Patients with obstructive pulmonary disease * Patients with decompensated diabetes, those with a fasting period of more than 12 hours -Acute alcohol intoxication * Chronic alcohol use * Who refuse to participate in the study * Who are not cooperative, do not speak Turkish * Who had known eye disease (glaucoma, retinal detachment), had a previous history of eye surgery, * Increased intracranial pressure findings (intracranial lesion, previous cerebrovascular diseases * Body mass index of \> 40kg/m2 * ASA \> III

Design outcomes

Primary

Measure	Time frame	Description
Optic Nerve Sheath Diamater	2 hours operation time	Optic nerve sheath diamater measurements of the patients were recorded before and during the surgery at specified time points (T0: awake, T1: High fresh gas flow after induction at the 10th min., T2: Inhalation anesthesia at the 30th min., T3: Inhalation anesthesia at the 60th min., T4: Inhalation anesthesia at the 90th min., T5: Before extubation).A typical optic nerve sheath is generally less than 5 mm in diameter, and diameters greater than 5.5 mm predict an ICP of ≥20 cm H2O with 100% sensitivity and specifity

Secondary

Measure	Time frame	Description
Peroperative Complications	2 hours operation time	Complications during the surgery (decreased oxygen levels, hypercapnia, hypotension, hypertension, bradycardia, tachycardia, rhythm disorders) were recorded.
Postoperative Complications	postop 20 minutes	Complications in the recovery room (respiratory distress, decreased oxygen levels, hypotension, hypertension, bradycardia, tachycardia, vomiting, rhythm disorders) were recorded.