Vienna Versus SARS-CoV-2 Virus Study

Conditions

COVID-19, SARS-CoV-2

Keywords

COVID-19, SARS-CoV-2, Immunity, Antibodies, Virus, Respiratory Virus, Immunoglobulins

Brief summary

This study examines the seroprevalence against SARS-CoV-2 in health care workers and patients at the Vienna General Hospital.

Detailed description

This study consists of 2 parts: a longitudinal study enrolling 3,000 health care professionals at the Vienna General Hospital testing their antibody status 6 times over a period of 12 months (Cohort A), and a serial cross-sectional study of 3,000 patients (i.e., a total of 9,000 patients) admitted to the Vienna General Hospital for non-COVID-19-related symptoms at 3 different time points during this pandemic (Cohort B).

Gyöngyösi M, Lukovic D, Mester-Tonczar J, Zlabinger K, Einzinger P, Spannbauer A, Schweiger V, Schefberger K, Samaha E, Bergler-Klein J, Riesenhuber M, Nitsche C, Hengstenberg C, Mucher P, Haslacher H, Breuer M, Strassl R, Puchhammer-Stöckl E, Loewe C, Beitzke D, Hasimbegovic E, Zelniker TA.

2023-09-296 citations

10.1038/s41541-023-00739-2

Comparison of the prevalence of SARS-CoV-2 nucleoprotein antibodies in healthcare workers and an unselected adult and paediatric all-comer patient population: insights from a longitudinal study of healthcare workers and concurrent serial cross-sectional studies of patients at an academic medical centre in Austria

Martin Riesenhuber, Christian Nitsche, Christoph J. Binder, Eva Schernhammer, Tanja Stamm et al. (12 authors)

BMJ Open2023-01-015 citations

10.1136/bmjopen-2022-063760

Interventions

DIAGNOSTIC_TESTLaboratory Analyses

Storage of serum for SARS-CoV-2-antibodies and biomarkers

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

Cohort A: Inclusion criteria: * Physicians * Nursing staff * Midwives * Medical-technical assistants (including medical, therapeutic and diagnostic healthcare staff, and medical and nursing assistants) * Administrative personnel with patient contact

Exclusion criteria

* Not employed at the Medical University of Vienna or the Vienna General Hospital * No signed informed consent Cohort B: Inclusion Criteria: ● Patients with available residual serum samples

Design outcomes

Primary

Measure	Time frame
Prevalence of antibody status in healthcare workers and in patients admitted for non-COVID-19 related symptoms over time	1 year

Secondary

Measure	Time frame
Incidence rate of sero-conversion	1 year
Identification of risk markers/factors for SARS-CoV-2 infection	1 year

Countries

Austria

Contacts

Primary ContactChristian Hengstenberg, Univ.-Prof.

christian.hengstenberg@meduniwien.ac.at+43 1 40400

Backup ContactThomas A Zelniker, DDr.

thomas.zelniker@meduniwien.ac.at+43 1 40400

Outcome results

None listed