Infertility, Female
Conditions
Keywords
IVF, HCG, GnRH agonist trigger
Brief summary
The aim of this randomized controlled trial is to determine whether co-administration of GnRH agonist and hCG for final oocyte maturation ( 40 and 34 h prior to oocyte retrieval , respectively) can increase the oocytes yield in patients with history of poor oocytes yield, despite normal response to COH, due to low (\<50%) number of oocytes retrieved per number of follicles \> 14 mm in diameter on day of hCG administration
Interventions
DRUGDouble trigger
Final follicular maturation is triggered by the co-administration of GnRH-agonist (Triptorelin acetate, decapeptyl 0.2 mg, Slough, United Kingdom) and 10000 IU of HCG, 40 and 34 h prior to oocyte retrieval, respectively
DRUGHCG trigger
Final follicular maturation is triggered by a dose of 10000 IU of HCG 36 h prior to oocyte retrieval
Sponsors
Riyadh Fertility and Reproductive Health center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Patients with history of poor oocytes yield in previous IVF attempt, despite normal response to COH, due to low (\<50%) number of oocytes retrieved per number of follicles \> 14 mm in diameter on day of hCG administration * Patients with 6 to 15 mature follicles on the day oocyte trigger in the current IVF-ET attempt
Exclusion criteria
* Endometriosis * PCOS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of oocytes retrieved | First day after oocyte retrieval |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| clinical pregnancy rate | First 5 weeks after oocyte retrieval | The presence of gestational sac detected by ultrasound examination |
Countries
Egypt
Contacts
Primary ContactUsama M Fouda, Prof.
Outcome results
None listed