Infertility, Female
Conditions
Keywords
IVF, HCG, GnRH agonist trigger
Brief summary
The aim of this randomized controlled trial is to determine whether co-administration of GnRH agonist and hCG for final oocyte maturation ( 40 and 34 h prior to oocyte retrieval , respectively) can increase the number of mature oocytes in patients with history of low proportion of mature oocytes in previous IVF cycle triggered by HCG.
Interventions
DRUGDouble trigger
Final follicular maturation is triggered by the coadministration of GnRH-agonist (Triptorelin acetate, decapeptyl 0.2 mg, Slough, United Kingdom) and 10000 IU of HCG, 40 and 34 h prior to oocyte retrieval, respectively
DRUGHCG trigger
Final follicular maturation is triggered by a dose of 10000 IU of HCG 36 h prior to oocyte retrieval
Sponsors
Riyadh Fertility and Reproductive Health center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Patients with history of low proportion of mature oocytes in previous IVF attempt (triggered by HCG). * Patients with 6 to 15 mature follicles on the day oocyte trigger in the current IVF-ET attempt
Exclusion criteria
* Endometriosis * PCOS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of oocytes retrieved | First day after oocyte retrieval |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | First 5 weeks after oocyte retrieval | The presence of gestational sac detected by ultrasound examination |
Countries
Egypt
Contacts
Primary ContactUsama M Fouda, Prof.
Outcome results
None listed