Musculoskeletal Diseases, Osteoarthritis, Osteoarthritis, Knee, Rheumatic Diseases
Conditions
Keywords
Low intensity pulsed ultrasound (LIPUS), High intensity continuous ultrasound, Knee pain, Knee stiffness, Randomized controlled trial, Myanmar, Osteotron
Brief summary
To compare the effects of low intensity pulsed ultrasound with high intensity continuous ultrasound in knee osteoarthritis
Detailed description
Knee osteoarthritis is a common disorder affecting elderly and obese. Currently, there are 3 types of treatment; pharmacological, non-pharmacological and surgery. Though ultrasound, a non-pharmacological treatment, is increasingly used in knee osteoarthritis, the advantages and disadvantages of low intensity pulsed ultrasound (LIPUS) and high intensity continuous ultrasound (HICUS) are yet to be clarified. Therefore, a randomized control trial will be done to compare LIPUS and HICUS in participants with knee osteoarthritis presenting to Department of Physical Medicine and Rehabilitation, Yangon General Hospital, Myanmar.
Interventions
Low intensity pulsed ultrasound therapy will use ultrasound with frequency of 1.5 MHz, power intensity of 30 mW/cm\^2 (0.03 W/cm\^2 ) and 20% duty cycle.
DEVICEHigh intensity continuous ultrasound
High intensity continuous ultrasound therapy will use ultrasound with frequency of 1 MHz, power intensity of 3 W/cm\^2 and 100% duty cycle.
Sponsors
University of Medicine 1 Yangon
Physical Medicine and Rehabilitation, Yangon General Hospital
Ministry of Health and Sports, Myanmar
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Participants with knee pain (VAS 3 to 6) * Kellgren and Lawrence grade 2 and 3 in X' ray knee joint
Exclusion criteria
* Rheumatoid arthritis, Gouty arthritis, Spondyloarthropathies, Metabolic arthropathies * Infection of knee joint * Tumor of knee joint * History of hypersensitivity to heat * Previous knee surgery in affected side * Intra-articular injection within previous 3 months * Participants taking treatment with other physical modalities such as low-level laser therapy and Trans Cutaneous Electrical Nerve Stimulation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual Analog Scale (VAS) | 8 weeks | It is one of the most commonly used measures of pain intensity and it is divided into 10 ordinal ratings with 0 being no pain and 10 being pain as bad as it could be. |
| Western Ontario McMaster University Osteoarthritis Index Inventory (WOMAC) | 8 weeks | This index measures clinically important symptoms of pain, stiffness and function. It consists of 23 questions (5 pain, 2 stiffness and 16 physical function) and the maximum score is 100, indicating the worst outcome while the minimum score is 0, indicating the best outcome. |
| Percentage of participants with skin irritation | 8 weeks | Skin irritation, a possible complication of ultrasound therapy, will be recorded as a dichotomous variable (i.e. present or absent). |
| Percentage of participants with tingling | 8 weeks | Tingling sensation, a possible complication of ultrasound therapy, will be recorded as a dichotomous variable (i.e. present or absent). |
| Percentage of participants with oedema | 8 weeks | Oedema, a possible complication of ultrasound therapy, will be recorded as a dichotomous variable (i.e. present or absent). |
| Percentage of participants with burns | 8 weeks | Burns, a possible complication of ultrasound therapy, will be recorded as a dichotomous variable (i.e. present or absent). |
Countries
Burma
Contacts
Primary ContactWunn Lei Thwe, M.B.,B.S
Outcome results
None listed