Different Timing for Early Laparoscopic Cholecystectomy in Acute Calcular Cholecystitis

Assessment of Different Timing for Early Laparoscopic Cholecystectomy in Acute Calcular Cholecystitis (Multicentric Study)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04405713

Acronym

ACC

Enrollment

900

Registered

2020-05-28

Start date

2018-04-01

Completion date

2020-03-25

Last updated

2020-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Cholecystitis

Keywords

Early laparoscopic cholecystectomy, postcholecystectomy bile injury, delay laparoscopic cholecystectomy

Brief summary

The ideal timing for ELC continues to be debatable in patients with acute calculator cholecystitis (ACC). This study was planned to identify the impact of different ELC timing in ACC on surgical outcomes in terms of safety and efficacy

Detailed description

This multicentric analysis involved of successive patients with ACC ELC between April 2018 and March 2020. Patients were divided into three groups according to the timing of the surgery: from the onset of symptoms within the first 3 days (group 1), between 4 and 7 days (group 2), and beyond 7 days (group 3). The primary outcome was the incidence of postoperative complications The secondary outcomes were conversion rate, blood loss, operative times, operational difficulty, the cost-benefit relationship, postoperative stay with each treatment line.

Interventions

PROCEDUREfrom the onset of symptoms within the first 3 days

ELC within 3 days of onset of ACC

PROCEDURE: from the onset of symptoms within the 4-7 days

ELC 4-7days of onset of ACC

PROCEDUREfrom the onset of symptoms beyond 7 days

ELC after 7days of onset of ACC

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Masking description

Patients were divided into three groups according to the timing of the surgery: from the onset of symptoms within the first 3 days (group 1), between 4 and 7 days (group 2) and beyond 7 days (group 3).

Intervention model description

Patients with ACC were divided into three groups according to the timing of the surgery: from the onset of symptoms within the first 3 days (group 1), between 4 and 7 days (group 2) and beyond 7 days (group 3).

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

ACC patients who underwent early LC

Exclusion criteria

Pregnancy, Acalculous cholecystitis, CBDS, Ascending cholangitis, Pancreatitis, ASA score 4, Patients scheduled for DLC with failed medical treatment.

Design outcomes

Primary

Measure	Time frame	Description
the incidence of postoperative morbidity	30 DAYS	the incidence of postoperative morbidity during the 30th day of postoperative procedure

Secondary

Measure	Time frame	Description
conversion rate	INTRAOPERATIVE	conversion rate to open cholecystectomy
blood loss	intraoperative	blood loss
hospital stay	30 days	overall hospital stay

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026