Resting Postural Tremor in Multiple Sclerosis

Spectral Analyses of Resting Postural Tremor Measured by Accelerometer and Gyroscope as a Predictive Tool of Multiple Sclerosis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04405479

Enrollment

Registered

2020-05-28

Start date

2021-05-01

Completion date

2024-12-30

Last updated

2024-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis

Keywords

Tremor, Accelerometer

Brief summary

Early diagnosis is a key factor for effective treatment of multiple sclerosis. Accelerometer and gyroscope measurement of tremor could screen potential motor control dysfunction and predict a risk for development of multiple sclerosis.

Detailed description

The aim of this study is to test whether specially developed accelerometer and gyroscope can differentiate pattern of resting postural tremor in healthy and people with multiple sclerosis. Spectral analysis and the correlation of the average signal spectra will be computed. Moreover, categorization based on the tremor component according to the maximum likelihood estimation will be done.

Interventions

BEHAVIORALExamination of tremor and upper hand functions

Participants will be only examined. They will not undergo any intervention.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

Group 1: * Definite diagnosis of MS * prevailed motor deficit of upper extremities, but without visible tremor * stable clinical status in the preceding 3 months * Expanded Disability Status Scale score (EDSS) ≥ 2 ≤ 7.5, and * no corticosteroid therapy in the preceding month Group 2: * Healthy volunteers in the age of 20-70 years will be employed * There will be defined as persons without any neurological disease diagnose at the time of the measurement.

Exclusion criteria

(both groups): Patients with factors disturbing mobility (e.g. stroke, pregnancy, fractures) were excluded from the study.

Design outcomes

Primary

Measure	Time frame	Description
Tremor	baseline	accelerometer (1 m·s-2)

Secondary

Measure	Time frame	Description
Hand grip strength	baseline	Hand dynamometer JAMA
Hand and arm function	baseline	Nine Hole Peg Test
Psychomotor processing speed	baseline	Coin Rotation Task

Countries

Czechia

Contacts

Primary ContactKamila Řasová, Ph.D.

kamila.rasova@gmail.com+420604511416

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026