Stroke
Conditions
Brief summary
This study uses a Doppler ultrasound technique being developed at the University of Leicester called "Brain Tissue Velocimetry" (Brain TV), to investigate brain tissue motion over the cardiac cycle.
Detailed description
Brain motion is highly sensitive to heart and brain biomechanics, but the impact of brain injury on brain tissue motion has yet to be explored. Preliminary brain tissue motion measurements from a small number of patients suggest that brain biomechanics may be disturbed in the presence of brain injury. This study combines transcranial tissue Doppler (TCTD) ultrasound with brain magnetic resonance imaging (MRI) to establish whether analysis of brain tissue motion provides clinically useful information for emergency diagnosis and monitoring of suspected stroke.
Interventions
DIAGNOSTIC_TESTTranscranial Tissue Doppler (TCTD)
Doppler ultrasound technique called Brain Tissue Velocimetry (Brain TV), to investigate brain tissue motion over the cardiac cycle.
DIAGNOSTIC_TESTBrain Magnetic Resonance Imaging
Brain MRI for investigation of brain tissue motion in the presence of suspected stroke.
Sponsors
Nihon Kohden
University of Leicester
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Participant (or consultee) is willing and able to give informed consent (or assent) for participation in the study. * Adult, aged 18 years or over. * Suspected stroke (any severity and any stroke type).
Exclusion criteria
* Unable (in the investigators' opinion), or unwilling, to comply with the study requirements. * Patients with pre-existing chronic brain conditions that may make affect informed consent, such as severe learning difficulties, dementia, or Alzheimer's disease, will be excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MRI measurement | Up to 5 days. | This study will perform brain MRI for brain tissue motion for selective patients with suspected stroke. |
| TCTD measurement | Up to 5 days. | The study will generate a library of Brain TV measurements for exploratory (descriptive) analysis and imaging of brain tissue pulsations in patients with suspected stroke to evaluate the potential for clinical device development. |
Countries
United Kingdom
Outcome results
None listed