Brain Death
Conditions
Keywords
Brain Death, Organ Donation
Brief summary
The purpose of the study is to describe the incidence of complications in brain death adult organ donors.
Detailed description
Pathophysiological changes following brain death may complicate the care of brain death donors. These complications negatively affects function of donated organs. Understanding these complications and its incidence is crucial for their appropriate management. The aim of this retrospective observational study is to evaluate the incidence of complications in adult brain death organ donors. Date will be collected from medical records of eligible patients admitted to intensive care unit for suspected brain death in whom brain death was confirmed and who become organ donors.
Interventions
None listed
Sponsors
Brno University Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age ≥18 years * confirmed brain death * organ donor
Exclusion criteria
\- age under 18 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hypotension | 48hours prior confirmation of brain death to ICU discharge | Hypotension is defined as increase of vasoactive drug dose by 20% or systolic blood pressure lower than 90 mmHg or need for fluid resuscitation after initial normovolemia was achieved |
| Serum lactate level | 48hours prior confirmation of brain death to ICU discharge | Maximal lactate level will be evaluated during ICU stay |
| Catecholamine storm | 48hours prior confirmation of brain death to ICU discharge | Catecholamine storm is defined as onset of tachycardia and/or hypertension |
| Myocardial dysfunction | 48hours prior confirmation of brain death to ICU discharge | Myocardial dysfunction is defined as left ventricle ejection fraction under 50% on trans-thoracic echocardiography or S-T segment depression or elevation or T wave negativity or positive troponin serum level |
| ARDS | 48hours prior confirmation of brain death to ICU discharge | ARDS is defined and stratified according to Berlin definition |
| Oxygenation index | 48hours prior confirmation of brain death to ICU discharge | Oxygenation index will be calculated as PaO2 divided by FiO2 |
| Diabetes insipidus | 48hours prior confirmation of brain death to ICU discharge | Diabetes insipidus is defines as urine output more than 4ml/kg per hour or urine specific gravity under 1010 |
| Renal dysfunction | 48hours prior confirmation of brain death to ICU discharge | Renal dysfunction is defined as presence of at least one of these criteria: absolute increase in serum creatinine ≥0.3 mg/dL (≥26.4 μmol/L) or increase in serum creatinine ≥1.5x above baseline or oliguria (urine output \<0.5 mL/kg per hour) for \>6 hours |
| Coagulopathy | 48hours prior confirmation of brain death to ICU discharge | Coagulopathy is defined as international normalised ratio above 1,5 or platelet count below 100 000 per microliter |
| Hypothermia | 48hours prior confirmation of brain death to ICU discharge | Body temperature below 36°C or need for external warming |
Countries
Czechia
Contacts
Primary ContactOndrej Hrdy, MD
Backup ContactViktor Agalarev, MD
Outcome results
None listed