Treatment of Periodontal Intrabony Defects With A-PRF+ or EMD

Efficacy of a New-generation Platelet-rich Fibrin vs. Enamel Matrix Derivatives in the Treatment of Periodontal Intrabony Defects : a Randomized Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04404374

Enrollment

Registered

2020-05-27

Start date

2018-06-27

Completion date

2020-12-31

Last updated

2021-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal Diseases

Keywords

Intrabony Defects, New-Generation Platelet-Rich Fibrin, Enamel Matrix Derivatives, Periodontal Regeneration, EMD, A-PRF+, Advanced Platelet-Rich Fibrin

Brief summary

The aim of this randomized clinical trial was to clinically evaluate and compare the healing of intrabony defects after treatment with advanced platelet-rich fibrin (A-PRF+) to enamel matrix derivatives (EMD) in periodontitis patients.

Detailed description

Thirty (30) intrabony defects of 18 patients (9 males, 9 females) were randomly divided in two treatment groups: test (n = 15) and control (n = 15). The intrabony defects were filled with A-PRF+ (n=15) in the test group, respectively with EMD in the control group, and fixed with sutures to ensure wound closure and stability.

Interventions

PROCEDUREA-PRF/EMD

Comparing healing effect of an autologous and a xenogenic product

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* no systemic diseases that could influence the outcome of the therapy, a good level of oral hygiene, he presence of a 2-, 3-, or combined 2-3-wall intrabony defect with a defect angle of 20-40 (+/- 5) degrees, with a minimum PPD of 6 mm and intrabony component of a minimum 4 mm as detected on radiographs, no smoking

Exclusion criteria

* systemic diseases that could influence the outcome of the therapy, poor oral hygiene, smoking, horizontal bone loss

Design outcomes

Primary

Measure	Time frame	Description
Periodontal clinical parameters - to determine the clinical attachment level (CAL)	Change from baseline after 6 month and after 12 month	With a calibrated periodontal probe we are examining the changes of periodontal probing depth (PPD) and gingival recession (GR) after surgical procedure in mm, the two parameters are used to determine the clinical attachment level (CAL).
Periodontal clinical parameters	Change from baseline after 6 month and after 12 month	With a calibrated periodontal probe we are examining the changes of periodontal probing depth (PPD) and gingival recession (GR) after surgical procedure in mm, the two parameters are used to determine the clinical attachment level (CAL).

Countries

Hungary

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 20, 2026