Hospital-acquired Pneumonia
Conditions
Keywords
0.12% chlorhexidine, Oral rinse, Hospital-acquired pneumonia
Brief summary
Chlorhexidine is a effective strategy in reducing ventilator associated pneumonia. However, it is unclear if prophylactic 0.12% chlorhexidine oral rinse can reduce the risk of non-ventilator hospital-acquired pneumonia among hospitalized patients.
Detailed description
Participants will be classified into three groups, applied twice a day by care givers. Oral colonization will be tested in the baseline, day-3, day-7, and at the discharge. Quantitation of colonization of the oral cavity by oral rinses and respiratory pathogens were measured.
Interventions
DRUG0.12% Chlorhexidine Oral Liquid Product
The intervention group 1 received 10ml 0.12% chlorhexidine solution for oral rinse twice a day.
DRUGListerine Oral Liquid Product
The intervention group 2 received 10ml Listerine solution for oral rinse twice a day.
OTHERNormal Saline Product
The control group received 10ml normal saline for oral rinse twice a day.
Sponsors
National Cheng-Kung University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Hospitalized patients \> 20 years old without ventilator
Exclusion criteria
* known hypersensitivity to or intolerance of Chlorhexidine or Listerine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oral bacterial colonization status | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| The rate of non-ventilator associated pneumonia | 1 year |
Countries
Taiwan
Outcome results
None listed