Structural Problems in Brainstem and Cervical Spine Cord in ME/CFS

The ME-SH (Myalgic Encephalomyelitis in Stockholm-Harvard) Study: Structural Problems in Brainstem and Cervical Spine Cord in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome(ME/CFS) - a Case-control Study

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04403854

Enrollment

100

Registered

2020-05-27

Start date

2021-04-01

Completion date

2026-03-31

Last updated

2020-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Fatigue Syndrome

Brief summary

A case control study on patients with ME/CFS and healthy controls on prevalence of cervical obstructions, Cerebro spinal fluid (CSF) pressure and laboratory findings.

Detailed description

50 patients and 50 healthy controls will undergo clinical exams and blood test of inflammatory and other findings as well as magnetic resonance imaging (MRI) with spectroscopy. The patients will undergo csf -sampling and measurements of CSF pressure.

Interventions

DIAGNOSTIC_TESTMRI

If possible with spectroscopy

PROCEDURESpinal Tap

together with CSF pressure estimate

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

Diagnose Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) according to Canada Consensus Criteria from 2003

Exclusion criteria

Bleeding abnormality Contraindication to Magnetic Resonance Imaging MRI Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Prevalance of cervical obstructions	Two days	MRI findings
Prevalence of Intracranial Hypertension	Two days	CSF measurements

Contacts

Primary ContactBjörn Bragee, MD

bjorn@bragee.se0854588875

Backup ContactBo C Bertilson, MD PhD

bo.bertilson@ki.seint4670732023

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026