to Treat the Vomiting Frequently Occur Post-laparoscopic by Different Anti Emetic Drugs
Conditions
Brief summary
To compare and evaluate the antiemetic effect and the safety of ondansetron, inhalational isopropyl alcohol and super hydration on adult patients after laparoscopic appendectomy.
Detailed description
This prospective double-blind study done on 240 patients admitted to surgical I.C.U after laparoscopic appendectomy. Those who had preoperative Koivuranta vomiting score of more than 3 enrolled in our study. Every group contains 80 patients. Patients of group A received ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours while patients of group B received isopropyl alcohol 70% inhalation every 15 min for 4 times then repeated after 6 hours. The last group C received intravenous normal saline at rate of 20 ml/kg over 30 minute and repeated by the same dose after 6 hours. The duration of the study was 24 hours post-operatively. As PONV is self-limited within 24 hours.
Interventions
DRUGOndansetron
ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours while patients of group
DRUGisopropyl alcohol 70% inhalation
inhalation every 15 min for 4 times then repeated after 6 hours
PROCEDURElaparoscopic appendectomy
all patients received post operatively after laparoscopic appenectomy
Sponsors
King Abdul Aziz Specialist Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
postoperative nausea and vomiting
Exclusion criteria
systemic disease as diabetes or hypertension local gastric diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| numbers of vomiting attacks | for one day | numbers of vomiting attacks recorded every 15 minutes for one day |
Countries
Saudi Arabia
Outcome results
None listed